Objective

2

To investigate the effect of single-port thoracoscopic lobectomy in the treatment of patients with peripheral lung cancer and moderate-to-severe reduction of lung function.

Methods

2

A total of 86 patients with peripheral lung cancer and moderate-to-severe reduction of lung function in our hospital were selected and divided into the single-port group and three-port group by random number table method

with 43 cases in each group.Patients in the single-port group were treated with single-port thoracoscopic lobectomy

and patients in the three-port group were treated with conventional three-port thoracoscopic lobectomy.The perioperative indicators were recorded

and the pulmonary function indicators including the percent of predicted forced expiratory volume in one second (FEV1%pred)

percent of predicted forced vital capacity (FVC%pred)

and percent of predicted maximum minute ventilation (MVV%pred)

inflammatory factors including the procalcitonin (PCT)

tumor necrosis factor-α (TNF-α)

C-reactive protein (CRP)

T lymphocyte subsets including CD3

+

CD4

+

CD4

+

/CD8

+

before surgery and 3 days and 7 days after surgery

and complications in the two groups were compared.

Results

2

Compared with the three-port group

the single-port group had shorter postoperative ambulation time and postoperative hospital stay

longer operation time

lower intraoperative blood loss and VAS score 3 days after operation

with statistically significant differences (

P

<

0.05).The FEV1%pred

FVC%pred and MVV%pred 3 days and 7 days after surgery in the two groups were lower than those before surgery

the FEV1%pred

FVC%pred and MVV%pred 7 days after surgery in the single-port group were higher than those in the three-port group (

P

<

0.05).The inflammatory factors 3 days after surgery in the two groups were higher than those before operation (

P

<

0.05)

and those in the single-port group were lower than those in the three-port group (

P

<

0.05);the serum levels of PCT

TNF-α and CRP 7 days after surgery in the two groups decreased

and those in the single-port group were lower than those in the three-port group (

P

<

0.05).The CD3

+

CD4

+

CD4

+

/CD8

+

3 days after surgery in the two groups were lower than those before surgery (

P

<

0.05)

and those in the the single-port group were higher than those in the three-port group (

P

<

0.05);the CD3

+

CD4

+

CD4

+

/CD8

+

7 days after surgery in the two groups all increased

and those in the single-port group were higher than those in the three-port group (

P

<

0.05).There was no significant difference in the incidence of complications between the two groups (

P

>

0.05).

Conclusion

2

Single-port thoracoscopic lobectomy in the treatment of peripheral lung cancer with moderate-to-severe reduction of lung function is safe and effective

which can achieve similar curative effect to conventional three-port thoracoscopic surgery.It has advantages in inflammation

immune function and early postoperative recovery

and is more acceptable to patients for its small surgical trauma and incision.