Objective

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To explore the anesthesia effect of phenobarbital sodium combined with xylazine hydrochloride compound anesthesia in surgical training beagles.

Methods

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A total of 89 healthy beagles intended for surgical training were randomly selected， and injected with phenobarbital sodium intravenously at a dose of 50 mg/kg， then injected with xylazine hydrochloride intramuscularly at a dose of 2 mg/kg for anesthesia induction，and xylazine hydrochloride was also used for additional anesthesia during operation. The time when the beagle entered into the light sleep state was recored. The time when the beagles entered into the state of anesthesia， the maintenance time of anesthesia and the additional anesthesia during operation were observed， and the recovery time and survival of the animals after operation were recorded.

Results

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After injecting phenobarbital sodium，61 beagles successfully entered into the light sleep state，of which 47 beagles entered into this state within 30 minutes.All beagles entered into the state of anesthesia within 15 minutes after injected with xylazine hydrochloride， with stable vital signs and good muscle relaxation during surgery. The maintenance time of anesthesia was more than 120 minutes.A total of 84 beagles woke up within 8 to 16 hours after surgery， and 5 beagles died within 10 hours after surgery.

Conclusion

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The phenobarbital sodium combined with xylazine hydrochloride in the anesthesia of beagles has the advantages of high stability， long maintenance time and relatively easy access， which can provide effective anesthesia for beagles surgery.