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羟考酮在老年胸腔镜下肺癌根治术后镇痛中的应用
Application of oxycodone in analgesia after thoracoscopic radical lung cancer surgery in elderly
- 局解手术学杂志 2024年33卷第11期 页码：937-940
- 作者机构：
1.徐州医科大学麻醉学院，江苏 徐州 221004
2.徐州医科大学附属沭阳医院麻醉科，江苏 沭阳223600
- 作者简介：
汪涛，E-mail：wangt35@126.com
- 基金信息：徐州医科大学江苏省重点实验室开放课题资助项目(XZSYSKF2020040)
DOI：10.11659/jjssx.03E024134
中图分类号： R971纸质出版日期：2024-11-25，
收稿日期：2024-03-25，
- 稿件说明：
移动端阅览
陶凤禹,汪涛,周巧林等.羟考酮在老年胸腔镜下肺癌根治术后镇痛中的应用[J].局解手术学杂志,2024,33(11):937-940.
TAO Feng-yu,WANG Tao,ZHOU Qiao-lin,et al.Application of oxycodone in analgesia after thoracoscopic radical lung cancer surgery in elderly[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(11):937-940.
陶凤禹,汪涛,周巧林等.羟考酮在老年胸腔镜下肺癌根治术后镇痛中的应用[J].局解手术学杂志,2024,33(11):937-940. DOI： 10.11659/jjssx.03E024134.
TAO Feng-yu,WANG Tao,ZHOU Qiao-lin,et al.Application of oxycodone in analgesia after thoracoscopic radical lung cancer surgery in elderly[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(11):937-940. DOI： 10.11659/jjssx.03E024134.
摘要
目的
2
探讨羟考酮在老年胸腔镜下肺癌根治术后镇痛中的应用效果。
方法
2
选取于徐州医科大学附属沭阳医院行胸腔镜下肺癌根治术的老年患者92例，按照随机数字表法分为对照组和观察组，每组46例。患者术后均使用静脉自控镇痛泵进行镇痛，对照组患者使用舒芬太尼2 μg/kg+右美托咪定0.5 μg/kg镇痛，观察组患者使用羟考酮0.5 mg/kg+右美托咪定0.5 μg/kg镇痛。比较2组患者术后不同时间点的疼痛程度、谵妄情况、炎症因子水平、认知功能和术后不良反应发生情况。
结果
2
观察组患者术后12 h、24 h、48 h的疼痛评分均显著低于对照组（
P
<
0.05）。观察组患者术后不良反应发生率显著低于对照组（
P
<
0.05）。观察组患者术后1 d、2 d的S100β、NSE和TNF-α水平均显著低于对照组（
P
<
0.05）。观察组患者术后1 d、2 d的认知功能评分均显著高于对照组（
P
<
0.05）。观察组患者术后1 d、2 d、3 d的谵妄发生率均显著低于对照组（
P
<
0.05）。
结论
2
羟考酮用于老年患者肺癌根治术后静脉自控镇痛，可以明显缓解疼痛，减少镇痛相关不良反应和术后谵妄发生，降低炎症因子水平，减轻认知功能受损程度，有利于患者术后恢复。
Abstract
Objective
2
To evaluate the efficacy of oxycodone in analgesia after thoracoscopic radical lung cancer surgery in elderly.
Methods
2
A total of 92 elderly patients who underwent thoracoscopic radical lung cancer surgery in the Affiliated Shuyang Hospital of Xuzhou Medical University were selected and randomly divided into the control group and the observation group according to the random number table method， with 46 cases in each group. Postoperative analgesia was administered with self-controlled intravenous analgesia pump for patients. Patients in the control group was anesthetized with sufentanil 2 μg/kg+dexmedetomidine 0.5 μg/kg， and patients in the observation group was anesthetized with oxycodone 0.5 mg/kg+dexmedetomidine 0.5 μg/kg. The pain degree，delirium， inflammatory factor level， cognitive function at different time points and postoperative adverse reactions of patients were compared between the two groups.
Results
2
The pain scores of patients 12 hours， 24 hours and 48 hours after surgery in the observation group were significantly lower than those in the control group （
P
<
0.05）. The incidence of postoperative adverse reactions in the observation group was significantly lower than that in the control group （
P
<
0.05）. The levels of S100β， NSE and TNF-α of patients 1 day and 2 days after surgery in the observation group were significantly lower than those in the control group（
P
<
0.05）.The cognitive function scores of patients 1 day and 2 days after surgery in the observation group were significantly higher than those in the control group （
P
<
0.05）. The incidences of delirium 1 day， 2 days and 3 days after surgery in the observation group were significantly lower than those in the control group （
P
<
0.05）.
Conclusion
2
The use of oxycodone for postoperative self-controlled intravenous analgesia in elderly patients after radical lung cancer surgery can significantly relieve pain， reduce analgesia-related adverse reactions and the incidence of postoperative delirium， decrease the inflammatory factors levels，and alleviate the degree of cognitive function impairment， which is beneficial to the postoperative recovery of patients.
关键词
羟考酮肺癌根治术老年炎症因子认知功能术后谵妄
Keywords
oxycodoneradical lung cancer surgeryelderlyinflammatory factorscognitive functionpostoperative delirium
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