血清miR-155、miR-23b在特发性肉芽肿乳腺炎和乳腺癌中的差异性表达及意义

何姣; 周瑜辉; 马晓霞; 齐晶

doi:10.11659/jjssx.03E023177

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血清miR-155、miR-23b在特发性肉芽肿乳腺炎和乳腺癌中的差异性表达及意义

临床研究 | 更新时间：2024-04-01

- 血清miR-155、miR-23b在特发性肉芽肿乳腺炎和乳腺癌中的差异性表达及意义
- Differential expression and significance of serum miR-155 and miR-23b in idiopathic granulomatous mastitis and breast cancer
- 局解手术学杂志 2024年33卷第3期页码：217-221
- 作者机构：
  
  西安交通大学第一附属医院乳腺外科，陕西西安 710061
- 作者简介：
- 基金信息：
  
  陕西省自然科学基础研究计划项目(2019JM-553)
- DOI：10.11659/jjssx.03E023177
  中图分类号： R655.8
- 纸质出版日期：2024-03-25，
  
  收稿日期：2023-03-28，
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何姣,周瑜辉,马晓霞等.血清miR-155、miR-23b在特发性肉芽肿乳腺炎和乳腺癌中的差异性表达及意义[J].局解手术学杂志,2024,33(03):217-221.

HE Jiao,ZHOU Yu-hui,MA Xiao-xia,et al.Differential expression and significance of serum miR-155 and miR-23b in idiopathic granulomatous mastitis and breast cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(03):217-221.
何姣,周瑜辉,马晓霞等.血清miR-155、miR-23b在特发性肉芽肿乳腺炎和乳腺癌中的差异性表达及意义[J].局解手术学杂志,2024,33(03):217-221. DOI： 10.11659/jjssx.03E023177.

HE Jiao,ZHOU Yu-hui,MA Xiao-xia,et al.Differential expression and significance of serum miR-155 and miR-23b in idiopathic granulomatous mastitis and breast cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(03):217-221. DOI： 10.11659/jjssx.03E023177.

摘要

目的

探讨miR-155、miR-23b在特发性肉芽肿乳腺炎（IGM）和乳腺癌（BC）鉴别诊断中的作用。

方法

选取2018年10月至2021年11月我院收治的32例IGM患者（ICM组）和40例BC患者（BC组），所有患者均经活检确诊。另外纳入33例健康女性作为对照组。比较患者的临床资料。采用实时荧光定量PCR检测血清miRNAs表达水平。采用受试者工作特征（

ROC

）曲线评估血清miR-155、miR-23b对IGM和BC的诊断价值。采用

Pearson

Abstract

Objective

To investigate the roles of miR-155 and miR-23b in the differential diagnosis of idiopathic granulomatous mastitis （IGM） and breast cancer （BC）.

Methods

A total of 32 patients with IGM （the ICM group） and 40 patients with BC （the BC group） admitted to our hospital from October 2018 to November 2021 were selected. All patients were confirmed by biopsy. In addition，33 healthy women were included as the control group. The clinical data of patients were compared. The expression levels of serum miRNAs were detected by real-time fluorescence quantitative PCR. The diagnostic value of serum miR-155 and miR-23b for IGM and BC was evaluated by

receiver operating characteristic

（

ROC

） curve.The

Pearson

correlation coefficient method was used to evaluate the correlation.

Results

There were statistically significant differences in the levels of CRP

WBC

Hct

CA19-9

CA15-3 and CA125 among the three groups (

0.05).The expression levels of serum miR-155，miR-16-5p，miR-21-5p，miR-210-3p，miR-222-3p and miR-29c-3p in the IGM group were higher than those in the control group （

0.001），and the expression level of serum miR-23b was lower than that in the control group （

0.001）. The expression levels of the above miRNAs of serum in the BC group were higher than those in the control group （

0.001）. The expression level of serum miR-155 in the BC group was lower than that in the IGM group （

0.001），and the expression level of serum miR-23b was higher than that in the IGM group （

0.001）.The

area under

the

ROC

curve

（

AUC

） for the differential diagnosis of IGM and BC by serum miR-155 and miR-23b levels were 0.722 （95%

：0.601 to 0.843） and 0.765 （95%

：0.657 to 0.874），respectively，with sensitivity of 81.00% and 77.50%，and specificity of 65.00% and 59.40%，respectively.The

AUC

of combined differential diagnosis was 0.869 （95%

：0.786 to 0.951），and the sensitivity and specificity were 84.10% and 92.50%，respectively. Serum miR-155 was positively correlated with WBC and CRP levels in the IGM group （

0.05），while serum miR-23b was negatively correlated with WBC and CRP levels （

0.05）.

Conclusion

Serum miR-155 and miR-23b are helpful in distinguishing IGM from BC，and can be used as targets for early differential diagnosis of IGM and BC.

关键词

特发性肉芽肿乳腺炎乳腺癌鉴别诊断miR-155miR-23b

Keywords

idiopathic granulomatous mastitisbreast cancerdifferential diagnosismiR-155miR-23b

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