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1. School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine,Sichuan,Chengdu,China,611137
2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Sichuan,Chengdu,China,611137
3. Institute of Translational Pharmacology and Clinical Application, Sichuan Academy of Chinese Medical Science,Sichuan,Chengdu,China,610041
纸质出版日期:2024,
网络出版日期:2024-1-1,
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Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword[J]. Genes & Diseases, 2024,1(1):367-381.
Yunchao Zhang, Jiayu Tang, Cheng Wang, et al. Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword[J]. Genes & Diseases, 2024,1(1):367-381.
Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword[J]. Genes & Diseases, 2024,1(1):367-381. DOI: 10.1016/j.gendis.2023.04.015.
Yunchao Zhang, Jiayu Tang, Cheng Wang, et al. Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword[J]. Genes & Diseases, 2024,1(1):367-381. DOI: 10.1016/j.gendis.2023.04.015.
The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate of cancer patients is still unsatisfactory. Therefore
it is necessary to further elucidate the molecular mechanisms involved in tumor development and drug resistance to improve cancer cure or survival rates. In recent years
autophagy has become a hot topic in the field of oncology research
which plays a double-edged role in tumorigenesis
progression
and drug resistance. Meanwhile
long non-coding RNA (lncRNA) has also been shown to regulate autophagy
and the two-sided nature of autophagy determines the dual regulatory role of autophagy-related lncRNAs (ARlncRNAs). Therefore
ARlncRNAs can be effective therapeutic targets for various cancers. Furthermore
the high abundance and stability of ARlncRNAs in tumor tissues make them promising biomarkers. In this review
we summarized the roles and mechanisms of ARlncRNAs in tumor cell proliferation
apoptosis
migration
invasion
drug resistance
angiogenesis
radiation resistance
and immune regulation. In addition
we described the clinical significance of these ARlncRNAs
including as biomarkers/therapeutic targets and their association with clinical drugs.
ApoptosisAutophagyBiomarkerCancerDrug resistanceLncRNA
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104 X. Ma, H. Ren, Y. Zhang, B. Wang, H. MaLncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway Environ Toxicol, 37 (12) (2022), pp. 3013-3027
105 F. Yang, Z.X. Peng, W.D. Ji, et al.LncRNA CCAT1 upregulates ATG5 to enhance autophagy and promote gastric cancer development by absorbing miR-140-3p Dig Dis Sci, 67 (8) (2022), pp. 3725-3741
106 H. Lin, X. Zhang, N. Feng, et al.LncRNA LCPAT1 mediates smoking/particulate matter 2.5-induced cell autophagy and epithelial-mesenchymal transition in lung cancer cells via RCC2 Cell Physiol Biochem, 47 (3) (2018), pp. 1244-1258
107 X. Han, Z. LiuLong non-coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR-197 Mol Med Rep, 23 (1) (2021), p. 60
108 Z. Cheng, G. Liu, C. Huang, X. ZhaoKLF5 activates lncRNA DANCR and inhibits cancer cell autophagy accelerating gastric cancer progression NPJ Genom Med, 6 (1) (2021), p. 75
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