RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

Hongxia Zhang; Yueya Zhong; Yuanming He; Yujia Xu; Ying Ren; Haixia Zhuang; Tong Sun; Zhigang Zhu; Xinliang Mao

doi:10.1016/j.gendis.2023.04.004

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RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

Rapid Communications | 更新时间：2024-02-04

- RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations
- RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations
- Genes & Diseases 2024年1卷第1期页码：87-90
- 作者机构：
  
  1. Institute of Clinical Pharmacology, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine,Guangdong,Guangzhou,China,510403
  2. Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University,Guangdong,Guangzhou,China,511436
  3. Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University,Jiangsu,Suzhou,China,215123
  4. Division of Hematology & Oncology, Department of Geriatrics, Guangzhou First People's Hospital, College of Medicine, South China University of Technology,Guangdong,Guangzhou,China,510180
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.04.004
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-1-1，
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RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations[J]. Genes & Diseases, 2024,1(1):87-90.

Hongxia Zhang, Yueya Zhong, Yuanming He, et al. RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations[J]. Genes & Diseases, 2024,1(1):87-90.
RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations[J]. Genes & Diseases, 2024,1(1):87-90. DOI： 10.1016/j.gendis.2023.04.004.

Hongxia Zhang, Yueya Zhong, Yuanming He, et al. RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations[J]. Genes & Diseases, 2024,1(1):87-90. DOI： 10.1016/j.gendis.2023.04.004.

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1 X. Xu, K. Han, X. Tang, et al.The ring finger protein RNF6 induces leukemia cell proliferation as a direct target of pre-B-cell leukemia homeobox 1 J Biol Chem, 291 (18) (2016), pp. 9617-9628

2 M. Tang, X. Zeng, J. Luo, et al.Gene commander in the trash heap: transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis Exp Cell Res, 401 (1) (2021), Article 112396

3 A. Satelli, S. LiVimentin in cancer and its potential as a molecular target for cancer therapy Cell Mol Life Sci, 68 (18) (2011), pp. 3033-3046

4 H. Zhuang, Y. Ren, C. Mao, et al.Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia J Biol Chem, 298 (9) (2022), Article 102314

5 Q.S. Zhu, K. Rosenblatt, K.L. Huang, et al.Vimentin is a novel AKT1 target mediating motility and invasion Oncogene, 30 (4) (2011), pp. 457-470

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