Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit <em>in vitro Plasmodium falciparum</em> multiplication in red blood cells

Mathieu Adjemout; Bruno Pouvelle; Fatou Thiam; Alassane Thiam; Magali Torres; Samia Nisar; Babacar Mbengue; Alioune Dieye; Pascal Rihet; Sandrine Marquet

doi:10.1016/j.gendis.2023.02.029

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Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

Rapid Communications | 更新时间：2024-02-04

- Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells
- Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells
- Genes & Diseases 2023年1卷第6期页码：2210-2214
- 作者机构：
  
  1. Institut National de la Santé Et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR) 0U109, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa,Marseille,France
  2. Groupe de Recherche Biotechnologie Appliquée et Bioprocédés Environnementaux (GRBA-BE), Ecole Supérieure Polytechnique, Université Cheikh Anta Diop de Dakar, Dakar 5,Senegal,BP500
  3. Pole D’Immunophysiopathologie & Maladies Infectieuses (IMI), Institut Pasteur de Dakar, Dakar BP,Senegal,220
  4. Service D’Immunologie, Université Cheikh Anta Diop de Dakar, Dakar 5,Senegal,BP500
  5. Aix Marseille University, CNRS,Marseille,France,13009
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.029
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-11-1，
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Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells[J]. Genes & Diseases, 2023,1(6):2210-2214.

Mathieu Adjemout, Bruno Pouvelle, Fatou Thiam, et al. Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells[J]. Genes & Diseases, 2023,1(6):2210-2214.
Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells[J]. Genes & Diseases, 2023,1(6):2210-2214. DOI： 10.1016/j.gendis.2023.02.029.

Mathieu Adjemout, Bruno Pouvelle, Fatou Thiam, et al. Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells[J]. Genes & Diseases, 2023,1(6):2210-2214. DOI： 10.1016/j.gendis.2023.02.029.

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1 S. Ma, S. Cahalan, G. LaMonte, et al.Common PIEZO1 allele in African populations causes RBC dehydration and attenuates Plasmodium infection Cell, 173 (2) (2018), pp. 443-455

2 C.N. Nguetse, N. Purington, E.R. Ebel, et al.A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans Proc Natl Acad Sci U S A, 117 (16) (2020), pp. 9074-9081

3 T. Thye, J.A. Evans, G. Ruge, et al.Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study J Hum Genet, 67 (1) (2022), pp. 65-67

4 S. Nisar, M. Torres, A. Thiam, et al.Identification of ATP2B4 regulatory element containing functional genetic variants associated with severe malaria Int J Mol Sci, 23 (9) (2022), p. 4849

5 A.D. Maher, P.W. KuchelThe Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytes Int J Biochem Cell Biol, 35 (8) (2003), pp. 1182-1197

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Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

DOI：10.1016/j.gendis.2023.02.029

摘要

Abstract

关键词

Keywords

references