PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

Feng Wang; Shitong Chen; Shihan Peng; Xujun Zhou; Houyi Tang; Hanghua Liang; Xi Zhong; He Yang; Xiaoxue Ke; MuHan Lü; Hongjuan Cui

doi:10.1016/j.gendis.2023.02.006

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PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

Full Length Articles | 更新时间：2024-02-04

- PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway
- PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway
- Genes & Diseases 2023年1卷第6期页码：2622-2638
- 作者机构：
  
  1. State Key Laboratory of Silkworm Genome Biology, Southwest University,Chongqing,China,400716
  2. Cancer Center, Medical Research Institute, Southwest University,Chongqing,China,400716
  3. Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Jiangyang District,Sichuan,Luzhou,China,646000
  4. Jinfeng Laboratory,Chongqing,China,401329
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.006
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-11-1，
扫描看全文
PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway[J]. Genes & Diseases, 2023,1(6):2622-2638.

Feng Wang, Shitong Chen, Shihan Peng, et al. PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway[J]. Genes & Diseases, 2023,1(6):2622-2638.
PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway[J]. Genes & Diseases, 2023,1(6):2622-2638. DOI： 10.1016/j.gendis.2023.02.006.

Feng Wang, Shitong Chen, Shihan Peng, et al. PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway[J]. Genes & Diseases, 2023,1(6):2622-2638. DOI： 10.1016/j.gendis.2023.02.006.

摘要

Abstract

Protein arginine methyltransferase 1 (PRMT1)

a type I PRMT

is overexpressed in gastric cancer (GC) cells. To elucidate the function of PRMT1 in GC

PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA (shRNA) or inhibited by PRMT1 inhibitors (AMI-1 or DCLX069)

which resulted in inhibition of GC cell proliferation

migration

invasion

and tumorigenesis

in vitro

and

in vivo

. MLX-interacting protein (MLXIP) and Kinectin 1 (KTN1) were identified as PRMT1-binding proteins. PRMT1 recruited MLXIP to the promoter of β-catenin

which induced β-catenin transcription and activated the β-catenin signaling pathway

promoting GC cell migration and metastasis. Furthermore

KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction between TRIM48 and PRMT1. Collectively

our findings reveal a mechanism by which PRMT1 promotes cell proliferation and metastasis mediated by the β-catenin signaling pathway.

关键词

Keywords

β-catenin signaling pathwayGastric cancerPRMT1Transcriptional regulationUbiquitination

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