The essential roles of m<sup>6</sup>A modification in osteogenesis and common bone diseases

Yuxi Gu; Yidan Song; Yihua Pan; Jun Liu

doi:10.1016/j.gendis.2023.01.032

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The essential roles of m⁶A modification in osteogenesis and common bone diseases

Review Articles | 更新时间：2024-02-04

- The essential roles of m⁶A modification in osteogenesis and common bone diseases
- The essential roles of m⁶A modification in osteogenesis and common bone diseases
- Genes & Diseases 2024年1卷第1期页码：335-345
- 作者机构：
  
  State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.032
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-1-1，
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The essential roles of m⁶A modification in osteogenesis and common bone diseases[J]. Genes & Diseases, 2024,1(1):335-345.

Yuxi Gu, Yidan Song, Yihua Pan, et al. The essential roles of m⁶A modification in osteogenesis and common bone diseases[J]. Genes & Diseases, 2024,1(1):335-345.
The essential roles of m⁶A modification in osteogenesis and common bone diseases[J]. Genes & Diseases, 2024,1(1):335-345. DOI： 10.1016/j.gendis.2023.01.032.

Yuxi Gu, Yidan Song, Yihua Pan, et al. The essential roles of m⁶A modification in osteogenesis and common bone diseases[J]. Genes & Diseases, 2024,1(1):335-345. DOI： 10.1016/j.gendis.2023.01.032.

摘要

Abstract

N6-methyladenosine (m

A) is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding RNAs. It affects the fate of the modified RNA

including its stability

splicing

and translation

and plays an important role in post-transcriptional regulation. Bones play a key role in supporting and protecting muscles and other organs

facilitating the movement of the organism

ensuring blood production

etc

. Bone diseases such as osteoarthritis

osteoporosis

and bone tumors are serious public health problems. The processes of bone development and osteogenic differentiation require the precise regulation of gene expression through epigenetic mechanisms including histone

DNA

and RNA modifications. As a reversible dynamic epigenetic mark

A modifications affect nearly every important biological process

cellular component

and molecular function

including skeletal development and homeostasis. In recent years

studies have shown that m

A modification is involved in osteogenesis and bone-related diseases. In this review

we summarized the proteins involved in RNA m

A modification and the latest progress in elucidating the regulatory role of m

A modification in bone formation and stem cell directional differentiation. We also discussed the pathological roles and potential molecular mechanisms of m

A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone defects and bone diseases.

关键词

Keywords

Bone diseasesm6A modificationOsteogenesisRegulatory roleStem cells

references

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The essential roles of m6A modification in osteogenesis and common bone diseases

The essential roles of m6A modification in osteogenesis and common bone diseases

DOI：10.1016/j.gendis.2023.01.032

摘要

Abstract

关键词

Keywords

references

The essential roles of m⁶A modification in osteogenesis and common bone diseases

The essential roles of m⁶A modification in osteogenesis and common bone diseases