RNA m<sup>6</sup>A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Zheng Zhang; Keren Zhou; Li Han; Andrew Small; Jianhuang Xue; Huilin Huang; Hengyou Weng; Rui Su; Brandon Tan; Chao Shen; Wei Li; Zhicong Zhao; Ying Qing; Xi Qin; Kitty Wang; Keith Leung; Mark Boldin; Chun-Wei Chen; David Ann; Zhijian Qian

doi:10.1016/j.gendis.2023.01.016

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RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Full Length Articles | 更新时间：2024-02-04

- RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression
- RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression
- Genes & Diseases 2024年1卷第1期页码：382-396
- 作者机构：
  
  1. Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia,CA,USA,91016
  2. Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte,CA,USA,91010
  3. School of Pharmacy, China Medical University,Liaoning,Shenyang,China,110001
  4. Tongji Hospital Affiliated to Tongji University, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University,Shanghai,China,200092
  5. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,Guangdong,Guangzhou,China,510060
  6. Guangzhou Laboratory,Guangdong,Guangzhou,China,510005
  7. Bioland Laboratory,Guangdong,Guangzhou,China,51005
  8. Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai,China,200127
  9. Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte,CA,USA,91010
  10. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville,FL,USA,32603
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.016
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-1-1，
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RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression[J]. Genes & Diseases, 2024,1(1):382-396.

Zheng Zhang, Keren Zhou, Li Han, et al. RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression[J]. Genes & Diseases, 2024,1(1):382-396.
RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression[J]. Genes & Diseases, 2024,1(1):382-396. DOI： 10.1016/j.gendis.2023.01.016.

Zheng Zhang, Keren Zhou, Li Han, et al. RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression[J]. Genes & Diseases, 2024,1(1):382-396. DOI： 10.1016/j.gendis.2023.01.016.

摘要

Abstract

the most common internal modification of mRNA

-methyladenosine (m

A) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. It was reported previously that m

A methyltransferase (writer)

methyltransferase-like 3 (METTL3) adds m

A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). However

it is unknown whether m

A modification also plays a role in the maturation process of pre-miRNAs and (if so) whether such a function contributes to tumorigenesis. Here

we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia (AML) patients

especially in relapsed patients

and plays an oncogenic role in AML. Moreover

YTHDF2 promotes expression of miR-126-3p (also known as miR-126

as it is the main product of precursor miR-126 (pre-miR-126))

a miRNA that was reported as an oncomiRNA in AML

through facilitating the processing of pre-miR-126 into mature miR-126. Mechanistically

YTHDF2 recognizes m

A modification in pre-miR-126 and recruits AGO2

a regulator of pre-miRNA processing

to promote the maturation of pre-miR-126.

YTHDF2

positively and negatively correlates with miR-126 and miR-126's downstream target genes

respectively

in AML patients

and forced expression of miR-126 could largely rescue

YTHDF2/Ythdf2

depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis

indicating that miR-126 is a functionally important target of YTHDF2 in AML. Overall

our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the therapeutic potential of targeting this axis for AML treatment

but also suggest that m

A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词

Keywords

AMLmiR-126N6-methyladenosinePre-miRNA maturationYTHDF2

references

1 X. Deng, R. Su, H. Weng, H. Huang, Z. Li, J. ChenRNA N(6)-methyladenosine modification in cancers: current status and perspectives Cell Res, 28 (5) (2018), pp. 507-517

2 H. Huang, H. Weng, J. Chenm(6)A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer Cancer Cell, 37 (3) (2020), pp. 270-288

3 H. Shi, J. Wei, C. HeWhere, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers Mol Cell, 74 (4) (2019), pp. 640-650

4 J. Liu, Y. Yue, D. Han, et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation Nat Chem Biol, 10 (2) (2014), pp. 93-95

5 P. Wang, K.A. Doxtader, Y. NamStructural basis for cooperative function of Mettl3 and Mettl14 methyltransferases Mol Cell, 63 (2) (2016), pp. 306-317

6 J. Wen, R. Lv, H. Ma, et al.Zc3h13 regulates nuclear RNA m(6)A methylation and mouse embryonic stem cell self-renewal Mol Cell, 69 (6) (2018), pp. 1028-1038.e6

7 Y. Yue, J. Liu, X. Cui, et al.VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation Cell Discov, 4 (2018), p. 10

8 E. Scholler, F. Weichmann, T. Treiber, et al.Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex RNA, 24 (4) (2018), pp. 499-512

9 J.A. Brown, C.G. Kinzig, S.J. DeGregorio, J.A. SteitzMethyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA Proc Natl Acad Sci U S A, 113 (49) (2016), pp. 14013-14018

10 K.E. Pendleton, B. Chen, K. Liu, et al.The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention Cell, 169 (5) (2017), pp. 824-835.e14

11 A.S. Warda, J. Kretschmer, P. Hackert, et al.Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs EMBO Rep, 18 (11) (2017), pp. 2004-2014

12 H. Shima, M. Matsumoto, Y. Ishigami, et al.S-adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1 Cell Rep, 21 (12) (2017), pp. 3354-3363

13 M. Mendel, K.M. Chen, D. Homolka, et al.Methylation of structured RNA by the m(6)A writer METTL16 is essential for mouse embryonic development Mol Cell, 71 (6) (2018), pp. 986-1000.e11

14 K.A. Doxtader, P. Wang, A.M. Scarborough, D. Seo, N.K. Conrad, Y. NamStructural basis for regulation of METTL16, an S-adenosylmethionine homeostasis factor Mol Cell, 71 (6) (2018), pp. 1001-1011.e4

15 R. Su, L. Dong, Y. Li, et al.METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis Nat Cell Biol, 24 (2) (2022), pp. 205-216

16 H. Ma, X. Wang, J. Cai, et al.N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation Nat Chem Biol, 15 (1) (2019), pp. 88-94

17 R. Su, L. Dong, C. Li, et al.R-2HG exhibits anti-tumor activity by targeting FTO/m(6)A/MYC/CEBPA signaling Cell, 172 (1–2) (2018), pp. 90-105.e23

18 C. Shen, Y. Sheng, A.C. Zhu, et al.RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia Cell Stem Cell, 27 (1) (2020), pp. 64-80.e9

19 H. Huang, H. Weng, W. Sun, et al.Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation Nat Cell Biol, 20 (3) (2018), pp. 285-295

20 D. Han, J. Liu, C. Chen, et al.Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells Nature, 566 (7743) (2019), pp. 270-274

21 X. Wang, B.S. Zhao, I.A. Roundtree, et al.N(6)-methyladenosine modulates messenger RNA translation efficiency Cell, 161 (6) (2015), pp. 1388-1399

22 H. Shi, X. Wang, Z. Lu, et al.YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA Cell Res, 27 (3) (2017), pp. 315-328

23 X. Wang, Z. Lu, A. Gomez, et al.N6-methyladenosine-dependent regulation of messenger RNA stability Nature, 505 (7481) (2014), pp. 117-120

24 D. Zhen, Y. Wu, Y. Zhang, et al.m(6)A reader: epitranscriptome target prediction and functional characterization of N (6)-methyladenosine (m(6)A) readers Front Cell Dev Biol, 8 (2020), p. 741

25 C.R. Alarcon, H. Goodarzi, H. Lee, X. Liu, S. Tavazoie, S.F. TavazoieHNRNPA2B1 is a mediator of m(6)a-dependent nuclear RNA processing events Cell, 162 (6) (2015), pp. 1299-1308

26 N. Liu, Q. Dai, G. Zheng, C. He, M. Parisien, T. PanN(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions Nature, 518 (7540) (2015), pp. 560-564

27 C.R. Alarcon, H. Lee, H. Goodarzi, N. Halberg, S.F. TavazoieN6-methyladenosine marks primary microRNAs for processing Nature, 519 (7544) (2015), pp. 482-485

28 D.P. Patil, C.K. Chen, B.F. Pickering, et al.m(6)A RNA methylation promotes XIST-mediated transcriptional repression Nature, 537 (7620) (2016), pp. 369-373

29 L.F.R. Gebert, I.J. MacRaeRegulation of microRNA function in animals Nat Rev Mol Cell Biol, 20 (1) (2019), pp. 21-37

30 S. Yendamuri, G.A. CalinThe role of microRNA in human leukemia: a review Leukemia, 23 (7) (2009), pp. 1257-1263

31 M. Ha, V.N. KimRegulation of microRNA biogenesis Nat Rev Mol Cell Biol, 15 (8) (2014), pp. 509-524

32 J.A. Wallace, R.M. O'ConnellMicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts Blood, 130 (11) (2017), pp. 1290-1301

33 K.N. Ivey, D. SrivastavamicroRNAs as developmental regulators Cold Spring Harbor Perspect Biol, 7 (7) (2015), Article a008144

34 C. Cheng, W. Li, Z. Zhang, et al.MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10) J Biol Chem, 288 (19) (2013), pp. 13748-13761

35 V. Rottiers, A.M. NaarMicroRNAs in metabolism and metabolic disorders Nat Rev Mol Cell Biol, 13 (4) (2012), pp. 239-250

36 E.R. Lechman, B. Gentner, S.W. Ng, et al.miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells Cancer Cell, 29 (2) (2016), pp. 214-228

37 B. Zhang, L.X.T. Nguyen, L. Li, et al.Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia Nat Med, 24 (4) (2018), pp. 450-462

38 J. Chen, O. Odenike, J.D. RowleyLeukaemogenesis: more than mutant genes Nat Rev Cancer, 10 (1) (2010), pp. 23-36

39 Z. Li, J. Lu, M. Sun, et al.Distinct microRNA expression profiles in acute myeloid leukemia with common translocations Proc Natl Acad Sci U S A, 105 (40) (2008), pp. 15535-15540

40 S. Mi, J. Lu, M. Sun, et al.MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia Proc Natl Acad Sci U S A, 104 (50) (2007), pp. 19971-19976

41 X. Jiang, J. Bugno, C. Hu, et al.Eradication of acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles Cancer Res, 76 (15) (2016), pp. 4470-4480

42 Z. Li, H. Huang, P. Chen, et al.miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia Nat Commun, 3 (2012), p. 688

43 D. Fletcher, E. Brown, J. Javadala, P. Uysal-Onganer, B.A. GuinnmicroRNA expression in acute myeloid leukaemia: new targets for therapy? EJHaem, 3 (3) (2022), pp. 596-608

44 B. Bhatnagar, R. GarzonClinical applications of MicroRNAs in acute myeloid leukemia: a mini-review Front Oncol, 11 (2021), Article 679022

45 H. Weng, H. Huang, H. Wu, et al.METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification Cell Stem Cell, 22 (2) (2018), pp. 191-205.e9

46 J. Paris, M. Morgan, J. Campos, et al.Targeting the RNA m(6)A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia Cell Stem Cell, 25 (1) (2019), pp. 137-148.e6

47 Y. Cheng, W. Xie, B.F. Pickering, et al.N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation Cancer Cell, 39 (7) (2021), pp. 958-972.e8

48 E. Yankova, W. Blackaby, M. Albertella, et al.Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia Nature, 593 (7860) (2021), pp. 597-601

49 L.P. Vu, B.F. Pickering, Y. Cheng, et al.The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells Nat Med, 23 (11) (2017), pp. 1369-1376

50 H. Weng, H. Huang, J. ChenRNA N (6)-methyladenosine modification in normal and malignant hematopoiesis Adv Exp Med Biol, 1143 (2019), pp. 75-93

51 Y. Qing, R. Su, J. ChenRNA modifications in hematopoietic malignancies: a new research frontier Blood, 138 (8) (2021), pp. 637-648

52 Z. Li, H. Weng, R. Su, et al.FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase Cancer Cell, 31 (1) (2017), pp. 127-141

53 L.P. Vu, B.F. Pickering, Y. Cheng, et al.The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells Nat Med, 23 (11) (2017), pp. 1369-1376

54 I. Barbieri, K. Tzelepis, L. Pandolfini, et al.Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control Nature, 552 (7683) (2017), pp. 126-131

55 Y. Huang, R. Su, Y. Sheng, et al.Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia Cancer Cell, 35 (2019), pp. 677-691

56 J. Wang, Y. Li, P. Wang, et al.Leukemogenic chromatin alterations promote AML leukemia stem cells via a KDM4C-ALKBH5-AXL signaling Axis Cell Stem Cell, 27 (1) (2020), pp. 81-97.e8

57 H. Weng, F. Huang, Z. Yu, et al.The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia Cancer Cell, 40 (2022), pp. 1-17

58 Z. Li, P. Qian, W. Shao, et al.Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion Cell Res, 28 (9) (2018), pp. 904-917

59 H. Wang, H. Zuo, J. Liu, et al.Loss of YTHDF2-mediated m(6)A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration Cell Res, 28 (10) (2018), pp. 1035-1038

60 Z. Chen, Y.L. Shao, L.L. Wang, et al.YTHDF2 is a potential target of AML1/ETO-HIF1alpha loop-mediated cell proliferation in t(8;21) AML Oncogene, 40 (22) (2021), pp. 3786-3798

61 L. Zhang, X. Zhao, J. Wang, et al.METTL3 suppresses neuropathic pain via modulating N6-methyladenosine-dependent primary miR-150 processing Cell Death Dis, 8 (1) (2022), p. 80

62 E.R. Lechman, B. Gentner, P. van Galen, et al.Attenuation of miR-126 activity expands HSC in vivo without exhaustion Cell Stem Cell, 11 (6) (2012), pp. 799-811

63 D.C. de Leeuw, F. Denkers, M.C. Olthof, et al.Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication Cancer Res, 74 (7) (2014), pp. 2094-2105

64 E.R. Lechman, B. Gentner, S.W.K. Ng, et al.miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells Cancer Cell, 29 (4) (2016), pp. 602-606

65 Z. Li, P. Chen, R. Su, et al.Overexpression and knockout of miR-126 both promote leukemogenesis Blood, 126 (17) (2015), pp. 2005-2015

66 L. Zhang, L.X.T. Nguyen, Y.C. Chen, et al.Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance Nat Commun, 12 (1) (2021), p. 6154

67 B. Zhang, L.X.T. Nguyen, D. Zhao, et al.Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML J Hematol Oncol, 14 (1) (2021), p. 122

68 F.O. Bagger, S. Kinalis, N. RapinBloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles Nucleic Acids Res, 47 (D1) (2019), pp. D881-D885

69 T. Haferlach, A. Kohlmann, L. Wieczorek, et al.Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group J Clin Oncol, 28 (15) (2010), pp. 2529-2537

70 H.H. Caicedo, D.A. Hashimoto, J.C. Caicedo, A. Pentland, G.P. PisanoOvercoming barriers to early disease intervention Nat Biotechnol, 38 (6) (2020), pp. 669-673

71 J.H. Li, S. Liu, H. Zhou, L.H. Qu, J.H. YangstarBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data Nucleic Acids Res, 42 (Database issue) (2014), pp. D92-D97

72 X. Jiang, H. Huang, Z. Li, et al.Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia Cancer Cell, 22 (4) (2012), pp. 524-535

73 Y. Qing, L. Dong, L. Gao, et al.R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis Mol Cell, 81 (5) (2021), pp. 922-939.e9

74 S. Ma, J. Yan, T. Barr, et al.The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity J Exp Med, 218 (8) (2021), Article e20210279

75 A. Kozomara, M. Birgaoanu, S. Griffiths-JonesmiRBase: from microRNA sequences to function Nucleic Acids Res, 47 (D1) (2019), pp. D155-D162

76 D.A. Forero, Y. Gonzalez-Giraldo, L.J. Castro-Vega, G.E. BarretoqPCR-based methods for expression analysis of miRNAs Biotechniques, 67 (4) (2019), pp. 192-199

77 T.D. Schmittgen, J. Jiang, Q. Liu, L. YangA high-throughput method to monitor the expression of microRNA precursors Nucleic Acids Res, 32 (4) (2004), p. e43

78 R. Su, L. Dong, Y. Li, et al.Targeting FTO suppresses cancer stem cell maintenance and immune evasion Cancer Cell, 38 (1) (2020), pp. 79-96.e11

79 L. Han, L. Dong, K. Leung, et al.METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism Cell Stem Cell, 30 (1) (2023), pp. 52-68.e13

80 A.V. Krivtsov, D. Twomey, Z. Feng, et al.Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9 Nature, 442 (7104) (2006), pp. 818-822

81 Y. Wang, A.V. Krivtsov, A.U. Sinha, et al.The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML Science, 327 (5973) (2010), pp. 1650-1653

82 M. Cusan, S.F. Cai, H.P. Mohammad, et al.LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPalpha-dependent enhancers in AML Blood, 131 (15) (2018), pp. 1730-1742

83 C.Y. Fong, O. Gilan, E.Y. Lam, et al.BET inhibitor resistance emerges from leukaemia stem cells Nature, 525 (7570) (2015), pp. 538-542

84 P. Rathert, M. Roth, T. Neumann, et al.Transcriptional plasticity promotes primary and acquired resistance to BET inhibition Nature, 525 (7570) (2015), pp. 543-547

85 M. Ye, H. Zhang, H. Yang, et al.Hematopoietic differentiation is required for initiation of acute myeloid leukemia Cell Stem Cell, 17 (5) (2015), pp. 611-623

86 S.M. Greenblatt, N. Man, P.J. Hamard, et al.CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis Cancer Cell, 34 (5) (2018), p. 868

87 X. Jiang, H. Huang, Z. Li, et al.Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia Cancer Cell, 22 (4) (2012), pp. 524-535

88 P. Chen, C. Price, Z. Li, et al.miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia Proc Natl Acad Sci U S A, 110 (28) (2013), pp. 11511-11516

89 X. Jiang, C. Hu, S. Arnovitz, et al.miR-22 has a potent anti-tumor role with therapeutic potential in acute myeloid leukemia Nat Commun, 7 (2016), Article 11452

90 X. Jiang, H. Huang, Z. Li, et al.miR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia Proc Natl Acad Sci USA, 109 (47) (2012), pp. 19397-19402

91 H. Weng, K. Lal, F.F. Yang, J. ChenThe pathological role and prognostic impact of miR-181 in acute myeloid leukemia Cancer Genet, 208 (5) (2015), pp. 225-229

92 J.Y. Youn, W.H. Dunham, S.J. Hong, et al.High-density proximity mapping reveals the subcellular organization of mRNA-associated granules and bodies Mol Cell, 69 (3) (2018), pp. 517-532.e11

93 H. Döhner, D.L. Longo, D.J. Weisdorf, C.D. BloomfieldAcute myeloid leukemia N Engl J Med, 373 (12) (2015), pp. 1136-1152

94 A. Burnett, M. Wetzler, B. LowenbergTherapeutic advances in acute myeloid leukemia J Clin Oncol, 29 (5) (2011), pp. 487-494

95 T. Velasco-Hernandez, P. Sawen, D. Bryder, J. CammengaPotential pitfalls of the mx1-cre system: implications for experimental modeling of normal and malignant hematopoiesis Stem Cell Rep, 7 (1) (2016), pp. 11-18

96 F.M. Healy, L.N. Dahal, J.R.E. Jones, Y. Floisand, J.F. WoolleyRecent progress in interferon therapy for myeloid malignancies Front Oncol, 11 (2021), Article 769628

97 O.H. Yilmaz, S.J. MorrisonThe PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells Blood Cells Mol Dis, 41 (1) (2008), pp. 73-76

98 A.E. Erson-Bensan, O. Begikm6A Modification and Implications for microRNAs MicroRNA, 6 (2) (2017), pp. 97-101

99 H. Wang, Q. Deng, Z. Lv, et al.N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1 Mol Cancer, 18 (1) (2019), p. 181

100 J.Z. Ma, F. Yang, C.C. Zhou, et al.METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6) -methyladenosine-dependent primary MicroRNA processing Hepatology, 65 (2) (2017), pp. 529-543

101 J. Han, J.Z. Wang, X. Yang, et al.METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner Mol Cancer, 18 (1) (2019), p. 110

102 P. Chen, S. Li, K. Zhang, et al.N(6)-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression Oncogene, 40 (37) (2021), pp. 5600-5612

103 H. Du, Y. Zhao, J. He, et al.YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex Nat Commun, 7 (2016), Article 12626

104 X. Liu, D.Y. Jin, M.T. McManus, Z. MourelatosPrecursor microRNA-programmed silencing complex assembly pathways in mammals Mol Cell, 46 (4) (2012), pp. 507-517

105 S. Diederichs, D.A. HaberDual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression Cell, 131 (6) (2007), pp. 1097-1108

106 D. Jin, J. Guo, Y. Wu, et al.m(6)A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC Mol Cancer, 19 (1) (2020), p. 40

107 A. Frohn, H.C. Eberl, J. Stohr, et al.Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells Mol Cell Proteomics, 11 (11) (2012), pp. 1442-1456

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RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

DOI：10.1016/j.gendis.2023.01.016

摘要

Abstract

关键词

Keywords

references

RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression