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1. Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton,Southampton,UK,SO17 1BJ
2. Institute for Life Sciences, University of Southampton,Southampton,UK,SO17 1BJ
纸质出版日期:2023,
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Synthetic lethal approaches to target cancers with loss of PTEN function[J]. Genes & Diseases, 2023,1(6):2511-2527.
Ayse Ertay, Rob M. Ewing, Yihua Wang. Synthetic lethal approaches to target cancers with loss of PTEN function[J]. Genes & Diseases, 2023,1(6):2511-2527.
Synthetic lethal approaches to target cancers with loss of PTEN function[J]. Genes & Diseases, 2023,1(6):2511-2527. DOI: 10.1016/j.gendis.2022.12.015.
Ayse Ertay, Rob M. Ewing, Yihua Wang. Synthetic lethal approaches to target cancers with loss of PTEN function[J]. Genes & Diseases, 2023,1(6):2511-2527. DOI: 10.1016/j.gendis.2022.12.015.
Phosphatase
and
tensin
homolog
(
PTEN)
is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3
4
5-triphosphate (PIP
3
) into phosphatidylinositol 4
5-bisphosphate (PIP
2
). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as
PTEN
has been challenging as it is difficult to restore the tumor suppressor functions. Therefore
focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.
CancerPTENSynthetic lethalityTumour suppressor geneWDHD1
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