Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Haochen Wang; Hui Yu; Tianyu Huang; Bin Wang; Lin Xiang

doi:10.1016/j.gendis.2022.12.012

您当前的位置：

首页 >

文章列表页 >

Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Review Articles | 更新时间：2024-02-04

- Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair
- Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair
- Genes & Diseases 2023年1卷第6期页码：2528-2539
- 作者机构：
  
  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
  2. Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.12.012
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-11-1，
扫描看全文
Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair[J]. Genes & Diseases, 2023,1(6):2528-2539.

Haochen Wang, Hui Yu, Tianyu Huang, et al. Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair[J]. Genes & Diseases, 2023,1(6):2528-2539.
Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair[J]. Genes & Diseases, 2023,1(6):2528-2539. DOI： 10.1016/j.gendis.2022.12.012.

Haochen Wang, Hui Yu, Tianyu Huang, et al. Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair[J]. Genes & Diseases, 2023,1(6):2528-2539. DOI： 10.1016/j.gendis.2022.12.012.

摘要

Abstract

Bone defects caused by diseases or surgery are a common clinical problem. Researchers are devoted to finding biological mechanisms that accelerate bone defect repair

which is a complex and continuous process controlled by many factors. As members of transcriptional costimulatory molecules

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play an important regulatory role in osteogenesis

and they affect cell function by regulating the expression of osteogenic genes in osteogenesis-related cells. Macrophages are an important group of cells whose function is regulated by YAP/TAZ. Currently

the relationship between YAP/TAZ and macrophage polarization has attracted increasing attention. In bone tissue

YAP/TAZ can realize diverse osteogenic regulation by mediating macrophage polarization. Macrophages polarize into M1 and M2 phenotypes under different stimuli. M1 macrophages dominate the inflammatory response by releasing a number of inflammatory mediators in the early phase of bone defect repair

while massive aggregation of M2 macrophages is beneficial for inflammation resolution and tissue repair

as they secrete many anti-inflammatory and osteogenesis-related cytokines. The mechanism of YAP/TAZ-mediated macrophage polarization during osteogenesis warrants further study and it is likely to be a promising strategy for bone defect repair. In this article

we review the effect of Hippo-YAP/TAZ signaling and macrophage polarization on bone defect repair

and highlight the regulation of macrophage polarization by YAP/TAZ.

关键词

Keywords

Bone defect repairHippo-YAP/TAZ signalingInflammationMacrophage polarizationOsteogenesis

references

1 R. Dimitriou, E. Jones, D. McGonagle, et al.Bone regeneration: current concepts and future directions BMC Med, 9 (2011), p. 66

2 H.A. Rather, D. Jhala, R. VasitaDual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering Mater Sci Eng C Mater Biol Appl, 103 (2019), Article 109761

3 G.E. Glass, J.K. Chan, A. Freidin, et al.TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells Proc Natl Acad Sci U S A, 108 (4) (2011), pp. 1585-1590

4 L.C. Gerstenfeld, T.J. Cho, T. Kon, et al.Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption J Bone Miner Res, 18 (9) (2003), pp. 1584-1592

5 H. Jiao, E. Xiao, D.T. GravesDiabetes and its effect on bone and fracture healing Curr Osteoporos Rep, 13 (5) (2015), pp. 327-335

6 H. Newman, Y.V. Shih, S. VargheseResolution of inflammation in bone regeneration: from understandings to therapeutic applications Biomaterials, 277 (2021), Article 121114

7 J. Pajarinen, T. Lin, E. Gibon, et al.Mesenchymal stem cell-macrophage crosstalk and bone healing Biomaterials, 196 (2019), pp. 80-89

8 H. Kovar, L. Bierbaumer, B. Radic-SarikasThe YAP/TAZ pathway in osteogenesis and bone sarcoma pathogenesis Cells, 9 (4) (2020), p. 972

9 L. Zhao, H. Guan, C. Song, et al.YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism Bone, 110 (2018), pp. 177-186

10 P.J. Murray, T.A. WynnProtective and pathogenic functions of macrophage subsets Nat Rev Immunol, 11 (11) (2011), pp. 723-737

11 T.A. Wynn, L. BarronMacrophages: master regulators of inflammation and fibrosis Semin Liver Dis, 30 (3) (2010), pp. 245-257

12 L. Vi, G.S. Baht, H. Whetstone, et al.Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis J Bone Miner Res, 30 (6) (2015), pp. 1090-1102

13 K.A. Alexander, M.K. Chang, E.R. Maylin, et al.Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model J Bone Miner Res, 26 (7) (2011), pp. 1517-1532

14 M.K. Chang, L.J. Raggatt, K.A. Alexander, et al.Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo J Immunol, 181 (2) (2008), pp. 1232-1244

15 C. Schlundt, T. El Khassawna, A. Serra, et al.Macrophages in bone fracture healing: their essential role in endochondral ossification Bone, 106 (2018), pp. 78-89

16 M.V. Thomas, D.A. PuleoInfection, inflammation, and bone regeneration: a paradoxical relationship J Dent Res, 90 (9) (2011), pp. 1052-1061

17 M. Zou, J. Sun, Z. XiangInduction of M2-type macrophage differentiation for bone defect repair via an interpenetration network hydrogel with a GO-based controlled release system Adv Healthc Mater, 10 (6) (2021), Article e2001502

18 Q.L. Ma, L. Fang, N. Jiang, et al.Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces Biomaterials, 154 (2018), pp. 234-247

19 S.S. Jin, D.Q. He, D. Luo, et al.A biomimetic hierarchical nanointerface orchestrates macrophage polarization and mesenchymal stem cell recruitment to promote endogenous bone regeneration ACS Nano, 13 (6) (2019), pp. 6581-6595

20 O.R. Mahon, D.C. Browe, T. Gonzalez-Fernandez, et al.Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner Biomaterials, 239 (2020), Article 119833

21 D.M. Mosser, J.P. EdwardsExploring the full spectrum of macrophage activation Nat Rev Immunol, 8 (12) (2008), pp. 958-969

22 X. Xue, X. Hong, Z. Li, et al.Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation Biomaterials, 134 (2017), pp. 22-30

23 J. Lee, B.U. Youn, K. Kim, et al.Mst2 controls bone homeostasis by regulating osteoclast and osteoblast differentiation J Bone Miner Res, 30 (9) (2015), pp. 1597-1607

24 H.W. Park, Y.C. Kim, B. Yu, et al.Alternative Wnt signaling activates YAP/TAZ Cell, 162 (4) (2015), pp. 780-794

25 J.X. Pan, L. Xiong, K. Zhao, et al.YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling Bone Res, 6 (2018), p. 18

26 S. Piccolo, S. Dupont, M. CordenonsiThe biology of YAP/TAZ: Hippo signaling and beyond Physiol Rev, 94 (4) (2014), pp. 1287-1312

27 A. Mussell, C. Frangou, J. ZhangRegulation of the Hippo signaling pathway by deubiquitinating enzymes in cancer Genes Dis, 6 (4) (2019), pp. 335-341

28 S. Ma, Z. Meng, R. Chen, et al.The Hippo pathway: biology and pathophysiology Annu Rev Biochem, 88 (2019), pp. 577-604

29 M.R. Zinatizadeh, S.R. Miri, P.K. Zarandi, et al.The Hippo tumor suppressor pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis Genes Dis, 8 (1) (2021), pp. 48-60

30 L. Zhang, F. Ren, Q. Zhang, et al.The TEAD/TEF family of transcription factor scalloped mediates Hippo signaling in organ size control Dev Cell, 14 (3) (2008), pp. 377-387

31 B. Zhao, X. Ye, J. Yu, et al.TEAD mediates YAP-dependent gene induction and growth control Genes Dev, 22 (14) (2008), pp. 1962-1971

32 A. Vassilev, K.J. Kaneko, H. Shu, et al.TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm Genes Dev, 15 (10) (2001), pp. 1229-1241

33 J. Huang, S. Wu, J. Barrera, et al.The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP Cell, 122 (3) (2005), pp. 421-434

34 B. Zhao, X. Wei, W. Li, et al.Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Genes Dev, 21 (21) (2007), pp. 2747-2761

35 J. Dong, G. Feldmann, J. Huang, et al.Elucidation of a universal size-control mechanism in Drosophila and mammals Cell, 130 (6) (2007), pp. 1120-1133

36 E.H.Y. Chan, M. Nousiainen, R.B. Chalamalasetty, et al.The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 Oncogene, 24 (12) (2005), pp. 2076-2086

37 J.R. Misra, K.D. IrvineThe Hippo signaling network and its biological functions Annu Rev Genet, 52 (2018), pp. 65-87

38 Y. Zheng, D. PanThe Hippo signaling pathway in development and disease Dev Cell, 50 (3) (2019), pp. 264-282

39 C. Lorthongpanich, K. Thumanu, K. Tangkiettrakul, et al.YAP as a key regulator of adipo-osteogenic differentiation in human MSCs Stem Cell Res Ther, 10 (2019), p. 402

40 J.H. Hong, E.S. Hwang, M.T. McManus, et al.TAZ, a transcriptional modulator of mesenchymal stem cell differentiation Science, 309 (5737) (2005), pp. 1074-1078

41 Q. Zhang, Y. Guo, H. Yu, et al.Receptor activity-modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo/Yap pathway J Cell Physiol, 234 (8) (2019), pp. 13969-13976

42 S. Dupont, L. Morsut, M. Aragona, et al.Role of YAP/TAZ in mechanotransduction Nature, 474 (7350) (2011), pp. 179-183

43 J.S. Park, M. Kim, N.J. Song, et al.A reciprocal role of the Smad4-taz axis in osteogenesis and adipogenesis of mesenchymal stem cells Stem Cell, 37 (3) (2019), pp. 368-381

44 Y. Tang, T. Feinberg, E.T. Keller, et al.Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation Nat Cell Biol, 18 (9) (2016), pp. 917-929

45 J. An, G. Li, J. Zhang, et al.GNAS knockdown suppresses osteogenic differentiation of mesenchymal stem cells via activation of Hippo signaling pathway J Cell Physiol, 234 (12) (2019), pp. 22299-22310

46 T. Panciera, L. Azzolin, M. Cordenonsi, et al.Mechanobiology of YAP and TAZ in physiology and disease Nat Rev Mol Cell Biol, 18 (12) (2017), pp. 758-770

47 Z. Chen, Q. Luo, C. Lin, et al.Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation Sci Rep, 6 (2016), Article 30322

48 C.D. Kegelman, J.M. Collins, M.P. Nijsure, et al.Gone caving: roles of the transcriptional regulators YAP and TAZ in skeletal development Curr Osteoporos Rep, 18 (5) (2020), pp. 526-540

49 X. Lin, H. Yang, L. Wang, et al.AP2a enhanced the osteogenic differentiation of mesenchymal stem cells by inhibiting the formation of YAP/RUNX2 complex and BARX1 transcription Cell Prolif, 52 (2019), Article e12522

50 E. Seo, U. Basu-Roy, P.H. Gunaratne, et al.SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage Cell Rep, 3 (6) (2013), pp. 2075-2087

51 L. Wang, X. You, S. Lotinun, et al.Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk Nat Commun, 11 (2020), p. 282

52 J.C. Crockett, N. Schütze, D. Tosh, et al.The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5 Endocrinology, 148 (12) (2007), pp. 5761-5768

53 W. Li, Y. Deng, B. Feng, et al.Mst1/2 kinases modulate glucose uptake for osteoblast differentiation and bone formation J Bone Miner Res, 33 (6) (2018), pp. 1183-1195

54 Z. Hossain, S.M. Ali, H.L. Ko, et al.Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1 Proc Natl Acad Sci U S A, 104 (5) (2007), pp. 1631-1636

55 J. Xiong, M. Almeida, C.A. O'BrienThe YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation Bone, 112 (2018), pp. 1-9

56 P.J. MurrayMacrophage polarization Annu Rev Physiol, 79 (2017), pp. 541-566

57 J.M. Davis, B. Cheng, M.M. Drake, et al.Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis Genes Dis, 9 (1) (2022), pp. 108-115

58 H.M. Rostam, P.M. Reynolds, M.R. Alexander, et al.Image based Machine Learning for identification of macrophage subsets Sci Rep, 7 (2017), p. 3521

59 M. Shayan, J. Padmanabhan, A.H. Morris, et al.Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization Acta Biomater, 75 (2018), pp. 427-438

60 A. Shapouri-Moghaddam, S. Mohammadian, H. Vazini, et al.Macrophage plasticity, polarization, and function in health and disease J Cell Physiol, 233 (9) (2018), pp. 6425-6440

61 F. De Santa, L. Vitiello, A. Torcinaro, et al.The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration Antioxidants Redox Signal, 30 (12) (2019), pp. 1553-1598

62 M. de Gaetano, D. Crean, M. Barry, et al.M1- and M2-type macrophage responses are predictive of adverse outcomes in human atherosclerosis Front Immunol, 7 (2016), p. 275

63 A. Mantovani, S.K. Biswas, M.R. Galdiero, et al.Macrophage plasticity and polarization in tissue repair and remodelling J Pathol, 229 (2) (2013), pp. 176-185

64 S.B. Goodman, E. Gibon, J. Gallo, et al.Macrophage polarization and the osteoimmunology of periprosthetic osteolysis Curr Osteoporos Rep, 20 (1) (2022), pp. 43-52

65 C. Diskin, E.M. Pålsson-McDermottMetabolic modulation in macrophage effector function Front Immunol, 9 (2018), p. 270

66 A.J. Covarrubias, H.I. Aksoylar, T. HorngControl of macrophage metabolism and activation by mTOR and Akt signaling Semin Immunol, 27 (4) (2015), pp. 286-296

67 Y. Yao, X.H. Xu, L. JinMacrophage polarization in physiological and pathological pregnancy Front Immunol, 10 (2019), p. 792

68 T. Satoh, O. Takeuchi, A. Vandenbon, et al.The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection Nat Immunol, 11 (10) (2010), pp. 936-944

69 X. Liao, N. Sharma, F. Kapadia, et al.Krüppel-like factor 4 regulates macrophage polarization J Clin Invest, 121 (7) (2011), pp. 2736-2749

70 C.J. Ferrante, S.J. LeibovichRegulation of macrophage polarization and wound healing Adv Wound Care, 1 (1) (2012), pp. 10-16

71 P.L. Graney, S. Ben-Shaul, S. Landau, et al.Macrophages of diverse phenotypes drive vascularization of engineered tissues Sci Adv, 6 (18) (2020), Article eaay6391

72 J. Muñoz, N.S. Akhavan, A.P. Mullins, et al.Macrophage polarization and osteoporosis: a review Nutrients, 12 (10) (2020), p. 2999

73 Y. Wang, W. Smith, D. Hao, et al.M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds Int Immunopharm, 70 (2019), pp. 459-466

74 X. He, S. Tan, Z. Shao, et al.Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases Genes Dis, 9 (5) (2022), pp. 1194-1207

75 A. Mortha, K. BurrowsCytokine networks between innate lymphoid cells and myeloid cells Front Immunol, 9 (2018), p. 191

76 M. Rath, I. Müller, P. Kropf, et al.Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages Front Immunol, 5 (2014), p. 532

77 T.A. Wynn, A. Chawla, J.W. PollardMacrophage biology in development, homeostasis and disease Nature, 496 (7446) (2013), pp. 445-455

78 S. Gordon, F.O. MartinezAlternative activation of macrophages: mechanism and functions Immunity, 32 (5) (2010), pp. 593-604

79 J. Lee, H. Byun, S.K. Madhurakkat Perikamana, et al.Current advances in immunomodulatory biomaterials for bone regeneration Adv Healthc Mater, 8 (4) (2019), Article e1801106

80 R. GruberOsteoimmunology: inflammatory osteolysis and regeneration of the alveolar bone J Clin Periodontol, 46 (Suppl 21) (2019), pp. 52-69

81 M. Tsukasaki, H. TakayanagiOsteoimmunology: evolving concepts in bone-immune interactions in health and disease Nat Rev Immunol, 19 (10) (2019), pp. 626-642

82 N.J. HorwoodMacrophage polarization and bone formation: a review Clin Rev Allergy Immunol, 51 (1) (2016), pp. 79-86

83 C. Schlundt, H. Fischer, C.H. Bucher, et al.The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time Acta Biomater, 133 (2021), pp. 46-57

84 K.I. Ko, L.S. Coimbra, C. Tian, et al.Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism Diabetologia, 58 (3) (2015), pp. 633-642

85 O. Kose, T. Arabaci, A. Kara, et al.Effects of melatonin on oxidative stress index and alveolar bone loss in diabetic rats with periodontitis J Periodontol, 87 (5) (2016), pp. e82-e90

86 F. Wang, L. Kong, W. Wang, et al.Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis Stem Cell Res Ther, 12 (2021), p. 288

87 Y. Zhang, T. Böse, R.E. Unger, et al.Macrophage type modulates osteogenic differentiation of adipose tissue MSCs Cell Tissue Res, 369 (2) (2017), pp. 273-286

88 F. Loi, L.A. Córdova, R. Zhang, et al.The effects of immunomodulation by macrophage subsets on osteogenesis in vitro Stem Cell Res Ther, 7 (2016), p. 15

89 S.J. Zhao, F.Q. Kong, J. Jie, et al.Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway Theranostics, 10 (1) (2020), pp. 17-35

90 M.P. Lutolf, J.A. HubbellSynthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nat Biotechnol, 23 (1) (2005), pp. 47-55

91 Y. Jin, J. Zhou, X. Zhao, et al.When 2D nanomaterials meet biomolecules: design strategies and hybrid nanostructures for bone tissue engineering J Mater Chem B, 10 (44) (2022), pp. 9040-9053

92 K.M. Hotchkiss, G.B. Reddy, S.L. Hyzy, et al.Titanium surface characteristics, including topography and wettability, alter macrophage activation Acta Biomater, 31 (2016), pp. 425-434

93 Y. Zhu, H. Liang, X. Liu, et al.Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration Sci Adv, 7 (14) (2021), Article eabf6654

94 G. Jiang, S. Li, K. Yu, et al.A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model Acta Biomater, 128 (2021), pp. 150-162

95 H. Shen, J. Shi, Y. Zhi, et al.Improved BMP2-CPC-stimulated osteogenesis in vitro and in vivo via modulation of macrophage polarization Mater Sci Eng C Mater Biol Appl, 118 (2021), Article 111471

96 D. Li, K. Chen, H. Tang, et al.A logic-based diagnostic and therapeutic hydrogel with multistimuli responsiveness to orchestrate diabetic bone regeneration Adv Mater, 34 (11) (2022), Article e2108430

97 Q. Zhao, M. Shi, C. Yin, et al.Dual-wavelength photosensitive nano-in-micro scaffold regulates innate and adaptive immune responses for osteogenesis Nano-Micro Lett, 13 (2020), p. 28

98 X. Sun, Z. Ma, X. Zhao, et al.Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus Bioact Mater, 6 (3) (2021), pp. 757-769

99 X. Dai, B.C. Heng, Y. Bai, et al.Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization Bioact Mater, 6 (7) (2021), pp. 2029-2038

100 J. Fu, Y. Li, Y. Zhang, et al.An engineered pseudo-macrophage for rapid treatment of bacteria-infected osteomyelitis via microwave-excited anti-infection and immunoregulation Adv Mater, 33 (41) (2021), Article e2102926

101 S. Thomann, S.M.E. Weiler, T. Wei, et al.YAP-induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer Liver Int, 41 (12) (2021), pp. 3011-3023

102 H. Rehrauer, L. Wu, W. Blum, et al.How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations Oncogene, 37 (20) (2018), pp. 2645-2659

103 Y.J. Huang, C.K. Yang, P.L. Wei, et al.Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways J Hematol Oncol, 10 (2017), p. 60

104 Y. Zhang, Y. Fan, X. Jing, et al.OTUD5-mediated deubiquitination of YAP in macrophage promotes M2 phenotype polarization and favors triple-negative breast cancer progression Cancer Lett, 504 (2021), pp. 104-115

105 Y. Feng, Y. Liang, X. Zhu, et al.The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz J Biol Chem, 293 (50) (2018), pp. 19290-19302

106 C. Li, Y. Jin, S. Wei, et al.Hippo signaling controls NLR family pyrin domain containing 3 activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury Hepatology, 70 (5) (2019), pp. 1714-1731

107 K. Song, H. Kwon, C. Han, et al.Yes-associated protein in kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis Hepatology, 72 (1) (2020), pp. 72-87

108 X. Zhou, W. Li, S. Wang, et al.YAP aggravates inflammatory bowel disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis Cell Rep, 27 (4) (2019), pp. 1176-1189.e5

109 K. Yang, J. Xu, M. Fan, et al.Lactate suppresses macrophage pro-inflammatory response to LPS stimulation by inhibition of YAP and NF-κB activation via GPR81-mediated signaling Front Immunol, 11 (2020), Article 587913

110 D. El Ouarrat, R. Isaac, Y.S. Lee, et al.TAZ is a negative regulator of PPARγ activity in adipocytes and TAZ deletion improves insulin sensitivity and glucose tolerance Cell Metabol, 31 (1) (2020), pp. 162-173.e5

111 M.M. Mia, D.M. Cibi, S.A.B. Abdul Ghani, et al.YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction PLoS Biol, 18 (12) (2020), Article e3000941

112 X. Guo, Y. Zhao, H. Yan, et al.Single tumor-initiating cells evade immune clearance by recruiting type II macrophages Genes Dev, 31 (3) (2017), pp. 247-259

113 X. Zhao, X. Wang, Y. You, et al.Nogo-B fosters HCC progression by enhancing Yap/Taz-mediated tumor-associated macrophages M2 polarization Exp Cell Res, 391 (1) (2020), Article 111979

114 Y.L. Zhang, Q. Li, X.M. Yang, et al.SPON2 promotes M1-like macrophage recruitment and inhibits hepatocellular carcinoma metastasis by distinct integrin-Rho GTPase-Hippo pathways Cancer Res, 78 (9) (2018), pp. 2305-2317

115 W. Kim, S.K. Khan, Y. Liu, et al.Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma Gut, 67 (9) (2018), pp. 1692-1703

116 C. Zhao, P. Qiu, M. Li, et al.The spatial form periosteal-bone complex promotes bone regeneration by coordinating macrophage polarization and osteogenic-angiogenic events Mater Today Bio, 12 (2021), Article 100142

117 V.S. Meli, H. Atcha, P.K. Veerasubramanian, et al.YAP-mediated mechanotransduction tunes the macrophage inflammatory response Sci Adv, 6 (49) (2020), Article eabb8471

118 P. Yuan, Y. Luo, Y. Luo, et al.A “sandwich” cell culture platform with NIR-responsive dynamic stiffness to modulate macrophage phenotypes Biomater Sci, 9 (7) (2021), pp. 2553-2561

119 A. Elosegui-Artola, I. Andreu, A.E.M. Beedle, et al.Force triggers YAP nuclear entry by regulating transport across nuclear pores Cell, 171 (6) (2017), pp. 1397-1410.e14

120 Y.L. Hao, S.J. Li, S.Y. Sun, et al.Elastic deformation behaviour of Ti-24Nb-4Zr-7.9Sn for biomedical applications Acta Biomater, 3 (2) (2007), pp. 277-286

121 Z. Tang, X. Wei, T. Li, et al.Three-dimensionally printed Ti2448 with low stiffness enhanced angiogenesis and osteogenesis by regulating macrophage polarization via Piezo1/YAP signaling axis Front Cell Dev Biol, 9 (2021), Article 750948

122 Q. Zhang, B. Wu, Y. Yuan, et al.CGRP-modulated M2 macrophages regulate osteogenesis of MC3T3-E1 via Yap1 Arch Biochem Biophys, 697 (2021), Article 108697

123 S. Li, Q. Li, Y. Zhu, et al.GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells Exp Cell Res, 387 (1) (2020), Article 111745

124 M. Lian, B. Sun, Y. Han, et al.A low-temperature-printed hierarchical porous sponge-like scaffold that promotes cell-material interaction and modulates paracrine activity of MSCs for vascularized bone regeneration Biomaterials, 274 (2021), Article 120841

125 A. Zhou, H. Yu, J. Liu, et al.Role of Hippo-YAP signaling in osseointegration by regulating osteogenesis, angiogenesis, and osteoimmunology Front Cell Dev Biol, 8 (2020), p. 780

126 L. Li, D.S.W. Ng, W.C. Mah, et al.A unique role for p53 in the regulation of M2 macrophage polarization Cell Death Differ, 22 (7) (2015), pp. 1081-1093

127 S.J. Zheng, S.E. Lamhamedi-Cherradi, P. Wang, et al.Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function Diabetes, 54 (5) (2005), pp. 1423-1428

128 L. He, J.H. Jhong, Q. Chen, et al.Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors Cell Rep, 37 (5) (2021), Article 109955

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury

The journey towards physiology and pathology: Tracing the path of neuregulin 4

The essential roles of m⁶A modification in osteogenesis and common bone diseases

The emerging role of Arid5a in cancer: A new target for tumors

Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets