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State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatrics & Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
纸质出版日期:2023,
网络出版日期:2023-11-1,
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Epigenetic regulation of mesenchymal stem cell aging through histone modifications[J]. Genes & Diseases, 2023,1(6):2443-2456.
Yanping Sun, Haoyu Zhang, Tao Qiu, et al. Epigenetic regulation of mesenchymal stem cell aging through histone modifications[J]. Genes & Diseases, 2023,1(6):2443-2456.
Epigenetic regulation of mesenchymal stem cell aging through histone modifications[J]. Genes & Diseases, 2023,1(6):2443-2456. DOI: 10.1016/j.gendis.2022.10.030.
Yanping Sun, Haoyu Zhang, Tao Qiu, et al. Epigenetic regulation of mesenchymal stem cell aging through histone modifications[J]. Genes & Diseases, 2023,1(6):2443-2456. DOI: 10.1016/j.gendis.2022.10.030.
Stem cell senescence and exhaustion
a hallmark of aging
lead to declines in tissue repair and regeneration in aged individuals. Emerging evidence has revealed that epigenetic regulation plays critical roles in the self-renew
lineage-commitment
survival
and function of stem cells. Moreover
epigenetic alterations are considered important drivers of stem cell dysfunction during aging. In this review
we focused on current knowledge of the histone modifications in the aging of mesenchymal stem cells (MSCs). The aberrant epigenetic modifications on histones
including methylation and acetylation
have been found in aging MSCs. By disturbing the expression of specific genes
these epigenetic modifications affect the self-renew
survival
and differentiation of MSCs. A set of epigenetic enzymes that write or erase these modifications are critical in regulating the aging of MSCs. Furthermore
we discussed the rejuvenation strategies based on epigenetics to prevent stem cell aging and/or rejuvenate senescent MSCs.
AgingEpigeneticHistone acetylationHistone methylationMesenchymal stem cell
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