Transcriptomic analysis reveals the promotion of lymph node metastasis by <em>Helicobacter pylori</em> infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma

Lang Zha; Xiong Guo; Xiaolong Liang; Yuedong Chen; Deyong Gan; Wenwen Li; Ziwei Wang; Hongyu Zhang

doi:10.1016/j.gendis.2022.10.027

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Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma

Full Length Articles | 更新时间：2024-02-04

- Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma
- Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma
- Genes & Diseases 2023年1卷第6期页码：2614-2621
- 作者机构：
  
  1. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400010
  2. Department of Gastrointestinal Surgery, The Tongliang Hospital of the First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400010
  3. Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University,Chongqing,China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.027
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-11-1，
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Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma[J]. Genes & Diseases, 2023,1(6):2614-2621.

Lang Zha, Xiong Guo, Xiaolong Liang, et al. Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma[J]. Genes & Diseases, 2023,1(6):2614-2621.
Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma[J]. Genes & Diseases, 2023,1(6):2614-2621. DOI： 10.1016/j.gendis.2022.10.027.

Lang Zha, Xiong Guo, Xiaolong Liang, et al. Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma[J]. Genes & Diseases, 2023,1(6):2614-2621. DOI： 10.1016/j.gendis.2022.10.027.

摘要

Abstract

Gastric carcinoma (GC) progression is mainly caused by local aggression and lymph node metastasis. However

some patients with early T-stage disease have lymph node metastasis

whereas some patients with late T-stage disease do not have lymph node metastasis

which indicates that invasion and metastasis are not always sequential in some GC patients. In the present study

the data of 101 GC cases were acquired from TCGA and divided into T-late-N-negative and T-early-N-positive groups according to pathological stages. A total of 338 genes were identified as differential genes between the T-late-N-negative and T-early-N-positive groups. GSEA showed that epithelial cell signaling in the

Helicobacter pylori

(

) infection pathway was enriched in the T-early-N-positive group. MB staining indicated that the

infection rate was 63% (39/62) in N-positive patients compared to 42% (16/38) in N-negative patients. To investigate the potential mechanism

we focused on the gene chemokine (C-X-C motif) receptor 2 (CXCR2)

which was not only clustered in the gene set of epithelial cells signaling in the

infection pathway but also significantly upregulated in T-early-N-positive GC by the analysis of the different genes based on the TCGA dataset. A meta-analysis showed that CXCR2 expression was positively correlated with N-stage but not with T-stage in GC. This study indicated that invasion and metastasis could be independent processes driven by different molecular mechanisms in some GC patients.

infection was a potential factor that promoted lymph node metastasis by upregulating CXCR2 expression.

关键词

Keywords

CXCR2Gastric carcinomaHelicobacter pyloriInvasionLymph node metastasis

references

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Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma

Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma

DOI：10.1016/j.gendis.2022.10.027

摘要

Abstract

关键词

Keywords

references