
浏览全部资源
扫码关注微信
1. Department of Pathology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
2. Department of Orthopedic Surgery, The Second Hospital University of South China,Hunan,Hengyang,China,421001
3. Department of Pathology, Xiangya Changde Hospital,Hunan,Changde,China,415000
4. Department of Burn and Plastic Surgery, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
5. Department of Pharmacy, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
6. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
纸质出版日期:2023,
网络出版日期:2023-11-1,
扫 描 看 全 文
The implication of pyroptosis in cancer immunology: Current advances and prospects[J]. Genes & Diseases, 2023,1(6):2339-2350.
Wei Liu, Jinwu Peng, Muzhang Xiao, et al. The implication of pyroptosis in cancer immunology: Current advances and prospects[J]. Genes & Diseases, 2023,1(6):2339-2350.
The implication of pyroptosis in cancer immunology: Current advances and prospects[J]. Genes & Diseases, 2023,1(6):2339-2350. DOI: 10.1016/j.gendis.2022.04.019.
Wei Liu, Jinwu Peng, Muzhang Xiao, et al. The implication of pyroptosis in cancer immunology: Current advances and prospects[J]. Genes & Diseases, 2023,1(6):2339-2350. DOI: 10.1016/j.gendis.2022.04.019.
Pyroptosis is a regulated cell death pathway involved in numerous human diseases
especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules
like caspases
gasdermin family and inflammasomes. In addition
increasing
in vitro
and
in vivo
studies have shown the significant linkage between pyroptosis and immune regulation of cancers. Pyroptosis-associated biomarkers regulate the infiltration of tumor immune cells
such as CD4
+
and CD8
+
T cells
thus strengthening the sensitivity to therapeutic strategies. In this review
we explained the relationship between pyroptosis and cancer immunology and focused on the significance of pyroptosis in immune regulation. We also proposed the future application of pyroptosis-associated biomarkers in basic research and clinical practices to address malignant behaviors. Exploration of the underlying mechanisms and biological functions of pyroptosis is critical for immune response and cancer immunotherapy.
Cancer immunologyImmune responseImmunotherapyPyroptosisInflammasomes
1 B. Pathakumari, G. Liang, W. LiuImmune defence to invasive fungal infections: a comprehensive review Biomed Pharmacother, 130 (2020), p. 110550
2 S. Cassim, J. PouyssegurTumor microenvironment: a metabolic player that shapes the immune response Int J Mol Sci, 21 (1) (2019), p. 157
3 L. Sun, X. Wang, J. Saredy, Z. Yuan, X. Yang, H. WangInnate-adaptive immunity interplay and redox regulation in immune response Redox Biol, 37 (2020), p. 101759
4 L. Jiang, Y.J. Wang, J. Zhao, et al.Direct tumor killing and immunotherapy through anti-SerpinB9 therapy Cell, 183 (5) (2020), pp. 1219-1233
5 M. Nishino, N.H. Ramaiya, H. Hatabu, F.S. HodiMonitoring immune-checkpoint blockade: response evaluation and biomarker development Nat Rev Clin Oncol, 14 (11) (2017), pp. 655-668
6 R.D. Schreiber, L.J. Old, M.J. SmythCancer immunoediting: integrating immunity's roles in cancer suppression and promotion Science, 331 (6024) (2011), pp. 1565-1570
7 S.R. Paludan, L.S. Reinert, V. HornungDNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer Nat Rev Immunol, 19 (3) (2019), pp. 141-153
8 I. Jorgensen, M. Rayamajhi, E.A. MiaoProgrammed cell death as a defence against infection Nat Rev Immunol, 17 (3) (2017), pp. 151-164
9 R. Tang, J. Xu, B. Zhang, et al.Ferroptosis, necroptosis, and pyroptosis in anticancer immunity J Hematol Oncol, 13 (1) (2020), p. 110
10 M.N. Messmer, A.G. Snyder, A. OberstComparing the effects of different cell death programs in tumor progression and immunotherapy Cell Death Differ, 26 (1) (2019), pp. 115-129
11 K. Hu, Z. Xu, L. Yao, Y. Yan, L. Zhou, J. LiIntegrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma Aging (Albany NY), 13 (21) (2021), pp. 24117-24135
12 J. Wei, Z. Xu, X. Chen, et al.Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma Mol Med Rep, 21 (1) (2020), pp. 360-370
13 L. Liu, B. SunNeutrophil pyroptosis: new perspectives on sepsis Cell Mol Life Sci, 76 (11) (2019), pp. 2031-2042
14 Z. Zhang, Z. Xu, Y. YanRole of a pyroptosis-related lncRNA signature in risk stratification and immunotherapy of ovarian cancer Front Med (Lausanne), 8 (2022), p. 793515
15 R. Karki, T.D. KannegantiDiverging inflammasome signals in tumorigenesis and potential targeting Nat Rev Cancer, 19 (4) (2019), pp. 197-214
16 D.A. Erkes, W. Cai, I.M. Sanchez, et al.Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis Cancer Discov, 10 (2) (2020), pp. 254-269
17 F. Xia, Y. Yan, C. ShenA prognostic pyroptosis-related lncRNAs risk model correlates with the immune microenvironment in colon adenocarcinoma Front Cell Dev Biol, 9 (2021), p. 811734
18 Z. Zhou, H. He, K. Wang, et al.Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells Science, 368 (6494) (2020), p. eaaz7548
19 S.K. Hsu, C.Y. Li, I.L. Lin, et al.Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment Theranostics, 11 (18) (2021), pp. 8813-8835
20 D. Chauhan, L. Vande Walle, M. LamkanfiTherapeutic modulation of inflammasome pathways Immunol Rev, 297 (1) (2020), pp. 123-138
21 Z. Xu, X. Wang, S. Zeng, X. Ren, Y. Yan, Z. GongApplying artificial intelligence for cancer immunotherapy Acta Pharm Sin B, 11 (11) (2021), pp. 3393-3405
22 Y. Yan, S. Zeng, Z. Gong, Z. XuClinical implication of cellular vaccine in glioma: current advances and future prospects J Exp Clin Cancer Res, 39 (1) (2020), p. 257
23 L. Zhang, Q.C. Yang, S. Wang, et al.Engineering multienzyme-mimicking covalent organic frameworks as pyroptosis inducers for boosting antitumor immunity Adv Mater, 34 (13) (2022), p. e2108174
24 B. Bai, Y. Yang, Q. Wang, et al.NLRP3 inflammasome in endothelial dysfunction Cell Death Dis, 11 (9) (2020), p. 776
25 Y. Xue, D. Enosi Tuipulotu, W.H. Tan, C. Kay, S.M. ManEmerging activators and regulators of inflammasomes and pyroptosis Trends Immunol, 40 (11) (2019), pp. 1035-1052
26 M. Lamkanfi, V.M. DixitInflammasomes and their roles in health and disease Annu Rev Cell Dev Biol, 28 (2012), pp. 137-161
27 S.K. Pachathundikandi, N. Blaser, H. Bruns, S. BackertHelicobacter pylori avoids the critical activation of NLRP3 inflammasome-mediated production of oncogenic mature IL-1β in human immune cells Cancers (Basel), 12 (4) (2020), p. 803
28 X. Zhang, C. Li, D. Chen, et al.H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion Inflamm Res, 71 (1) (2022), pp. 141-155
29 J. Huang, P. Fan, M. Liu, et al.Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells BMC Pharmacol Toxicol, 22 (1) (2021), p. 62
30 G.A. Ward, K.L. McGraw, F. Abbas-Aghababazadeh, et al.Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes Blood Adv, 5 (8) (2021), pp. 2216-2228
31 V.M. Ringel-Scaia, N. Beitel-White, M.F. Lorenzo, et al.High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity EBioMedicine, 44 (2019), pp. 112-125
32 R.E. KastInhibiting the NLRP3 inflammasome with methylene blue as treatment adjunct in myelodysplasia Front Oncol, 8 (2018), p. 280
33 D.A. Sallman, T. Cluzeau, A.A. Basiorka, A. ListUnraveling the pathogenesis of MDS: the NLRP3 inflammasome and pyroptosis drive the MDS phenotype Front Oncol, 6 (2016), p. 151
34 K.L. DeYoung, M.E. Ray, Y.A. Su, et al.Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma Oncogene, 15 (4) (1997), pp. 453-457
35 G. Patsos, A. Germann, J. Gebert, S. DihlmannRestoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells Int J Cancer, 126 (8) (2010), pp. 1838-1849
36 S.M. Woerner, M. Kloor, Y. Schwitalle, et al.The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers Genes Chromosomes Cancer, 46 (12) (2007), pp. 1080-1089
37 M. Zhang, C. Jin, Y. Yang, et al.AIM2 promotes non-small-cell lung cancer cell growth through inflammasome-dependent pathway J Cell Physiol, 234 (11) (2019), pp. 20161-20173
38 T.L. Roberts, A. Idris, J.A. Dunn, et al.HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA Science, 323 (5917) (2009), pp. 1057-1060
39 V. Hornung, A. Ablasser, M. Charrel-Dennis, et al.AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature, 458 (7237) (2009), pp. 514-518
40 T. Fernandes-Alnemri, J.W. Yu, P. Datta, J. Wu, E.S. AlnemriAIM2 activates the inflammasome and cell death in response to cytoplasmic DNA Nature, 458 (7237) (2009), pp. 509-513
41 T. Jin, A. Perry, J. Jiang, et al.Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor Immunity, 36 (4) (2012), pp. 561-571
42 V.A. Rathinam, Z. Jiang, S.N. Waggoner, et al.The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses Nat Immunol, 11 (5) (2010), pp. 395-402
43 J.E. Wilson, A.S. Petrucelli, L. Chen, et al.Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt Nat Med, 21 (8) (2015), pp. 906-913
44 L. Corrales, S.R. Woo, J.B. Williams, S.M. McWhirter, T.W. Dubensky Jr., T.F. GajewskiAntagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA J Immunol, 196 (7) (2016), pp. 3191-3198
45 D. So, H.W. Shin, J. Kim, et al.Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense Oncogene, 37 (38) (2018), pp. 5191-5204
46 C.E. Vrentas, P.M. Boggiatto, S.C. Olsen, S.H. Leppla, M. MoayeriCharacterization of the NLRP1 inflammasome response in bovine species Innate Immun, 26 (4) (2020), pp. 301-311
47 D.C. Johnson, M.C. Okondo, E.L. Orth, et al.DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes Cell Death Dis, 11 (8) (2020), p. 628
48 A.R. Griswold, H.C. Huang, D.A. BachovchinThe NLRP1 inflammasome induces pyroptosis in human corneal epithelial cells Invest Ophthalmol Vis Sci, 63 (3) (2022), p. 2
49 L. Ghimire, S. Paudel, L. Jin, P. Baral, S. Cai, S. JeyaseelanNLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function PLoS Pathog, 14 (9) (2018), p. e1007308
50 W. Liu, J. Liu, W. Wang, Y. Wang, X. OuyangNLRP6 induces pyroptosis by activation of caspase-1 in gingival fibroblasts J Dent Res, 97 (12) (2018), pp. 1391-1398
51 N. Naseer, M.S. Egan, V.M. Reyes Ruiz, et al.Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication PLoS Pathog, 18 (1) (2022), p. e1009718
52 S. Zhu, S. Ding, P. Wang, et al.Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells Nature, 546 (7660) (2017), pp. 667-670
53 J. Shi, Y. Zhao, K. Wang, et al.Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death Nature, 526 (7575) (2015), pp. 660-665
54 N. Van Opdenbosch, M. LamkanfiCaspases in cell death, inflammation, and disease Immunity, 50 (6) (2019), pp. 1352-1364
55 N.A. Thornberry, H.G. Bull, J.R. Calaycay, et al.A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes Nature, 356 (6372) (1992), pp. 768-774
56 S.M. Gaikwad, Z. Phyo, A.Q. Arteaga, et al.A small molecule stabilizer of the MYC G4-quadruplex induces endoplasmic reticulum stress, senescence and pyroptosis in multiple myeloma Cancers (Basel), 12 (10) (2020), p. 2952
57 M.M. Nyiramana, S.B. Cho, E.J. Kim, et al.Sea hare hydrolysate-induced reduction of human non-small cell lung cancer cell growth through regulation of macrophage polarization and non-apoptotic regulated cell death pathways Cancers (Basel), 12 (3) (2020), p. 726
58 Y. Song, X. Wu, Y. Xu, et al.HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome Int J Biol Sci, 16 (15) (2020), pp. 2924-2937
59 A. Takasu, A. Masui, M. Hamada, T. Imai, S. Iwai, Y. YuraImmunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells Cancer Gene Ther, 23 (4) (2016), pp. 107-113
60 T. Arakelian, K. Oosterhuis, E. Tondini, et al.Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination Vaccine, 40 (13) (2022), pp. 2087-2098
61 J. Shi, Y. Zhao, Y. Wang, et al.Inflammatory caspases are innate immune receptors for intracellular LPS Nature, 514 (7521) (2014), pp. 187-192
62 S. Yokoyama, S. Nakayama, L. Xu, A.L. Pilon, S. KimuraSecretoglobin 3A2 eliminates human cancer cells through pyroptosis Cell Death Discov, 7 (1) (2021), p. 12
63 Y. Jiao, L. Wang, L. Lu, et al.The role of caspase-4 and NLRP1 in MCF7 cell pyroptosis induced by hUCMSC-secreted factors Stem Cells Int, 2020 (2020), p. 8867115
64 T. Ishii, H. Hayakawa, T. Sekiguchi, N. Adachi, M. SekiguchiRole of Auf1 in elimination of oxidatively damaged messenger RNA in human cells Free Radic Biol Med, 79 (2015), pp. 109-116
65 N. Kayagaki, I.B. Stowe, B.L. Lee, et al.Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling Nature, 526 (7575) (2015), pp. 666-671
66 W.T. He, H. Wan, L. Hu, et al.Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion Cell Res, 25 (12) (2015), pp. 1285-1298
67 N. Rana, G. Privitera, H.C. Kondolf, et al.GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis Cell, 185 (2) (2022), pp. 283-298
68 W. Deng, Y. Bai, F. Deng, et al.Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis Nature, 602 (7897) (2022), pp. 496-502
69 Z. Zheng, W. Deng, Y. Bai, et al.The lysosomal rag-ragulator complex licenses RIPK1 and caspase-8-mediated pyroptosis by Yersinia Science, 372 (6549) (2021), p. eabg0269
70 C.L. Evavold, I. Hafner-Bratkovič, P. Devant, et al.Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway Cell, 184 (17) (2021), pp. 4495-4511
71 S. Xia, Z. Zhang, V.G. Magupalli, et al.Gasdermin D pore structure reveals preferential release of mature interleukin-1 Nature, 593 (7860) (2021), pp. 607-611
72 P. Broz, P. Pelegrín, F. ShaoThe gasdermins, a protein family executing cell death and inflammation Nat Rev Immunol, 20 (3) (2020), pp. 143-157
73 J. Ding, K. Wang, W. Liu, et al.Pore-forming activity and structural autoinhibition of the gasdermin family Nature, 535 (7610) (2016), pp. 111-116
74 R.A. Aglietti, A. Estevez, A. Gupta, et al.GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes Proc Natl Acad Sci U S A, 113 (28) (2016), pp. 7858-7863
75 X. Chen, W.T. He, L. Hu, et al.Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis Cell Res, 26 (9) (2016), pp. 1007-1020
76 X. Liu, Z. Zhang, J. Ruan, et al.Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores Nature, 535 (7610) (2016), pp. 153-158
77 L. Sborgi, S. Rühl, E. Mulvihill, et al.GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death EMBO J, 35 (16) (2016), pp. 1766-1778
78 K. Wang, Q. Sun, X. Zhong, et al.Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis Cell, 180 (5) (2020), pp. 941-955
79 K.C. Barnett, J.P. TingMitochondrial GSDMD pores DAMPen pyroptosis Immunity, 52 (3) (2020), pp. 424-426
80 Z. Liu, L. Gan, Y. Xu, et al.Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue J Pineal Res, 63 (1) (2017), p. e12414
81 M.C. Okondo, D.C. Johnson, R. Sridharan, et al.DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis Nat Chem Biol, 13 (1) (2017), pp. 46-53
82 M.C. Okondo, S.D. Rao, C.Y. Taabazuing, et al.Inhibition of Dpp8/9 activates the Nlrp1b inflammasome Cell Chem Biol, 25 (3) (2018), pp. 262-267
83 C.Y. Taabazuing, M.C. Okondo, D.A. BachovchinPyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages Cell Chem Biol, 24 (4) (2017), pp. 507-514
84 L. Van Laer, E.H. Huizing, M. Verstreken, et al.Nonsyndromic hearing impairment is associated with a mutation in DFNA5 Nat Genet, 20 (2) (1998), pp. 194-197
85 Z. Zhang, Y. Zhang, S. Xia, et al.Gasdermin E suppresses tumour growth by activating anti-tumour immunity Nature, 579 (7799) (2020), pp. 415-420
86 M. Guo, Z.D. Xiao, Z. Dai, et al.The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancers Nucleic Acids Res, 48 (22) (2020), pp. 12618-12631
87 P. Zhao, M. Wang, M. Chen, et al.Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy Biomaterials, 254 (2020), p. 120142
88 J. Yu, S. Li, J. Qi, et al.Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells Cell Death Dis, 10 (3) (2019), p. 193
89 Q. Ding, W. Zhang, C. Cheng, et al.Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo J Cell Physiol, 235 (3) (2020), pp. 2911-2924
90 J. Hu, W. Pei, M. Jiang, et al.DFNA5 regulates immune cells infiltration and exhaustion Cancer Cell Int, 22 (1) (2022), p. 107
91 S. Wang, M.J. Zhang, Z.Z. Wu, et al.GSDME is related to prognosis and response to chemotherapy in oral cancer J Dent Res, 101 (7) (2022), pp. 848-858
92 K. Akino, M. Toyota, H. Suzuki, et al.Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer Cancer Sci, 98 (1) (2007), pp. 88-95
93 A. Liu, L. Shen, N. Li, L. Shen, Z. LiPan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer J Transl Med, 20 (1) (2022), p. 109
94 G. Tan, C. Lin, C. Huang, et al.Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E Cancer Lett, 529 (2022), pp. 1-10
95 F. Su, J. Duan, J. Zhu, H. Fu, X. Zheng, C. GeLong non-coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation-induced pyroptosis via microRNA-448/gasdermin E in colorectal cancer cells Int J Oncol, 59 (4) (2021), p. 79
96 J. Hou, R. Zhao, W. Xia, et al.PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis Nat Cell Biol, 22 (10) (2020), pp. 1264-1275
97 C. Berkel, E. CacanDifferential expression and copy number variation of gasdermin (GSDM) family members, pore-forming proteins in pyroptosis, in normal and malignant serous ovarian tissue Inflammation, 44 (6) (2021), pp. 2203-2216
98 D.L. Elion, M.E. Jacobson, D.J. Hicks, et al.Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers Cancer Res, 78 (21) (2018), pp. 6183-6195
99 Q. Yu, M. Zhang, Q. Ying, et al.Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment Cell Death Dis, 10 (3) (2019), p. 218
100 T. Zhang, D.M. Wu, P.W. Luo, et al.CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition Cell Death Dis, 13 (2) (2022), p. 167
101 S.L. Chen, L.L. Liu, S.X. Lu, et al.HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis Mol Oncol, 11 (9) (2017), pp. 1225-1240
102 D. Zhivaki, J.C. KaganNLRP3 inflammasomes that induce antitumor immunity Trends Immunol, 42 (7) (2021), pp. 575-589
103 L. Li, M. Jiang, L. Qi, et al.Pyroptosis, a new bridge to tumor immunity Cancer Sci, 112 (10) (2021), pp. 3979-3994
104 P. Yu, X. Zhang, N. Liu, L. Tang, C. Peng, X. ChenPyroptosis: mechanisms and diseases Signal Transduct Target Ther, 6 (1) (2021), p. 128
105 Y. Xiao, T. Zhang, X. Ma, et al.Microenvironment-responsive prodrug-induced pyroptosis boosts cancer immunotherapy Adv Sci (Weinh), 8 (24) (2021), p. e2101840
106 Z. Qian, Y. Zhao, C. Wan, et al.Pyroptosis in the initiation and progression of atherosclerosis Front Pharmacol, 12 (2021), p. 652963
107 S. An, H. Hu, Y. Li, Y. HuPyroptosis plays a role in osteoarthritis Aging Dis, 11 (5) (2020), pp. 1146-1157
108 J. Wu, S. Lin, B. Wan, B. Velani, Y. ZhuPyroptosis in liver disease: new insights into disease mechanisms Aging Dis, 10 (5) (2019), pp. 1094-1108
109 J. Lin, A. Cheng, K. Cheng, et al.New insights into the mechanisms of pyroptosis and implications for diabetic kidney disease Int J Mol Sci, 21 (19) (2020), p. 7057
110 X. Lu, T. Guo, X. ZhangPyroptosis in cancer: friend or foe? Cancers (Basel), 13 (14) (2021), p. 3620
111 L. Yao, J. Li, Z. Xu, Y. Yan, K. HuGSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma Aging (Albany NY), 14 (6) (2022), pp. 2758-2774
112 G. Lin, Q. Feng, F. Zhan, F. Yang, Y. Niu, G. LiGeneration and analysis of pyroptosis-based and immune-based signatures for kidney renal clear cell carcinoma patients, and cell experiment Front Genet, 13 (2022), p. 809794
113 Y.F. Tan, M. Wang, Z.Y. Chen, L. Wang, X.H. LiuInhibition of BRD4 prevents proliferation and epithelial-mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis Cell Death Dis, 11 (4) (2020), p. 239
114 X. Zhang, P. Zhang, L. An, et al.Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis Acta Pharm Sin B, 10 (8) (2020), pp. 1397-1413
115 D.C. Johnson, C.Y. Taabazuing, M.C. Okondo, et al.DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia Nat Med, 24 (8) (2018), pp. 1151-1156
116 C.B. Zhou, J.Y. FangThe role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection Biochim Biophys Acta Rev Cancer, 1872 (1) (2019), pp. 1-10
117 F. Awad, E. Assrawi, C. Jumeau, et al.Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation PLoS One, 12 (4) (2017), p. e0175336
118 Y. Jiao, T. Zhang, C. Zhang, et al.Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury Crit Care, 25 (1) (2021), p. 356
119 A. Mónaco, S. Chilibroste, L. Yim, J.A. Chabalgoity, M. MorenoInflammasome activation, NLRP3 engagement and macrophage recruitment to tumor microenvironment are all required for Salmonella antitumor effect Cancer Immunol Immunother, 71 (9) (2022), pp. 2141-2150
120 F.Y. Mai, P. He, J.Z. Ye, et al.Caspase-3-mediated GSDME activation contributes to cisplatin- and doxorubicin-induced secondary necrosis in mouse macrophages Cell Prolif, 52 (5) (2019), p. e12663
121 S. GhoshCisplatin: the first metal based anticancer drug Bioorg Chem, 88 (2019), p. 102925
122 D. Chen, S. Guo, X. Tang, et al.Combination of ruthenium (II) polypyridyl complex Δ-Ru1 and Taxol enhances the anti-cancer effect on Taxol-resistant cancer cells through Caspase-1/GSDMD-mediated pyroptosis J Inorg Biochem, 230 (2022), p. 111749
123 E. Yue, G. Tuguzbaeva, X. Chen, et al.Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma Phytomedicine, 56 (2019), pp. 286-294
124 X. Shen, H. Wang, C. Weng, H. Jiang, J. ChenCaspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity Cell Death Dis, 12 (2) (2021), p. 186
125 Z. Huang, Q. Zhang, Y. Wang, et al.Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy Am J Cancer Res, 10 (12) (2020), pp. 4287-4307
126 Z. Cheng, Z. Li, L. Gu, et al.Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis J Cancer, 13 (2) (2022), pp. 715-727
127 Y. Wang, W. Gao, X. Shi, et al.Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin Nature, 547 (7661) (2017), pp. 99-103
128 B. Pulendran, M.M. DavisThe science and medicine of human immunology Science, 369 (6511) (2020), p. eaay4014
129 K. TsuchiyaSwitching from apoptosis to pyroptosis: gasdermin-elicited inflammation and antitumor immunity Int J Mol Sci, 22 (1) (2021), p. 426
130 P. Orning, E. Lien, K.A. FitzgeraldGasdermins and their role in immunity and inflammation J Exp Med, 216 (11) (2019), pp. 2453-2465
131 S. Hamarsheh, R. ZeiserNLRP3 inflammasome activation in cancer: a double-edged sword Front Immunol, 11 (2020), p. 1444
132 D. Zhivaki, F. Borriello, O.A. Chow, et al.Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity Cell Rep, 33 (7) (2020), p. 108381
133 C. Hage, S. Hoves, L. Strauss, et al.Sorafenib induces pyroptosis in macrophages and triggers natural killer cell-mediated cytotoxicity against hepatocellular carcinoma Hepatology, 70 (4) (2019), pp. 1280-1297
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621