<em>De novo</em> nucleotide biosynthetic pathway and cancer

Jie Chen; Siqi Yang; Yingge Li; Xu Ziwen; Pingfeng Zhang; Qibin Song; Yi Yao; Huadong Pei

doi:10.1016/j.gendis.2022.04.018

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De novo nucleotide biosynthetic pathway and cancer

Review Articles | 更新时间：2024-02-04

- De novo nucleotide biosynthetic pathway and cancer
- De novo nucleotide biosynthetic pathway and cancer
- Genes & Diseases 2023年1卷第6期页码：2331-2338
- 作者机构：
  
  1. Cancer Center, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430062
  2. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,,.C.,Washington,D,USA,20057
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.04.018
  中图分类号：
- 纸质出版日期：2023，
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De novo nucleotide biosynthetic pathway and cancer[J]. Genes & Diseases, 2023,1(6):2331-2338.

Jie Chen, Siqi Yang, Yingge Li, et al. De novo nucleotide biosynthetic pathway and cancer[J]. Genes & Diseases, 2023,1(6):2331-2338.
De novo nucleotide biosynthetic pathway and cancer[J]. Genes & Diseases, 2023,1(6):2331-2338. DOI： 10.1016/j.gendis.2022.04.018.

Jie Chen, Siqi Yang, Yingge Li, et al. De novo nucleotide biosynthetic pathway and cancer[J]. Genes & Diseases, 2023,1(6):2331-2338. DOI： 10.1016/j.gendis.2022.04.018.

摘要

Abstract

De novo

nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation. Thus

the dysregulation of the

de novo

nucleotide biosynthetic pathway contributes to the development of many human diseases

such as cancer. It has been shown that many enzymes in this pathway are overactivated in different cancers. In this review

we summarize and update the current knowledge on the

de novo

nucleotide biosynthetic pathway

regulatory mechanisms

its role in tumorigenesis

and potential targeting opportunities.

关键词

Keywords

Biosynthetic pathwayCancerde novo synthesisMetabolismNucleotide

references

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DOI：10.1016/j.gendis.2022.04.018

摘要

Abstract

关键词

Keywords

references