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1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran,47176
3. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
4. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
5. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran,47176
纸质出版日期:2023,
网络出版日期:2023-11-1,
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Critical involvement of circular RNAs in virus-associated cancers[J]. Genes & Diseases, 2023,1(6):2296-2305.
Arghavan Zebardast, Tayebeh Latifi, Moein shirzad, et al. Critical involvement of circular RNAs in virus-associated cancers[J]. Genes & Diseases, 2023,1(6):2296-2305.
Critical involvement of circular RNAs in virus-associated cancers[J]. Genes & Diseases, 2023,1(6):2296-2305. DOI: 10.1016/j.gendis.2022.04.009.
Arghavan Zebardast, Tayebeh Latifi, Moein shirzad, et al. Critical involvement of circular RNAs in virus-associated cancers[J]. Genes & Diseases, 2023,1(6):2296-2305. DOI: 10.1016/j.gendis.2022.04.009.
Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host's infected cells. Seven viruses (e.g.
human papillomavirus (HPV)
Epstein–Barr virus (EBV)
Kaposi's sarcoma herpesvirus (KSHV)
Hepatitis B virus (HBV)
Hepatitis C virus (HCV)
Human T-lymphotropic virus (HTLV)
and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently
growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs)
due to the absence of 5′ and 3′ ends
have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs
as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore
understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence
in this review
we will focus on emerging roles of virus-encoded circRNAs in multiple cancers
including cervical cancer
gastric cancer
Merkel cell carcinoma
nasopharyngeal carcinoma
Kaposi cancer
and liver cancer.
CancerCircular RNANeoplasmsOncogenesViruses
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