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1. Department of Hematology, The Affiliated Hospital of Southwest Medical University,Sichuan,Luzhou,China,646000
2. Department of Hematology, Lanzhou University Second Hospital,Gansu,Lanzhou,China,730000
纸质出版日期:2023,
网络出版日期:2023-11-1,
扫 描 看 全 文
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations[J]. Genes & Diseases, 2023,1(6):2306-2319.
Tao Ma, Yan Chen, Zhi-Gang Yi, et al. BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations[J]. Genes & Diseases, 2023,1(6):2306-2319.
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations[J]. Genes & Diseases, 2023,1(6):2306-2319. DOI: 10.1016/j.gendis.2022.03.004.
Tao Ma, Yan Chen, Zhi-Gang Yi, et al. BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations[J]. Genes & Diseases, 2023,1(6):2306-2319. DOI: 10.1016/j.gendis.2022.03.004.
The bromodomain and extra-terminal (BET) proteins act as “readers” for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes. BET protein is associated with transcriptional elongation of genes such as
c-MYC
and
BCL-2
and is involved in the regulation of cell cycle and apoptosis. Meanwhile
BET inhibitors (BETi) have regulatory effects on immune checkpoints
immune cells
and cytokine expression. The role of BET proteins and BETi in a variety of tumors has been studied. This paper reviews the recent research progress of BET and BETi in hematologic tumors (mainly leukemia
lymphoma and multiple myeloma) from cellular level studies
animal studies
clinical trials
drug combination
etc. BETi has a promising future in hematologic tumors
and future research directions may focus on the combination with other drugs to improve the efficacy.
BETBRD4Clinical trialsHematologic tumorsImmunityMYC
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