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1. Cardiology Department, The First Affiliated Hospital of Anhui Medical University,Anhui,Hefei,China,230022
2. Anhui Medical University,Anhui,Hefei,China,230032
纸质出版日期:2023,
网络出版日期:2023-11-1,
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Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury[J]. Genes & Diseases, 2023,1(6):2285-2295.
Yu Yang, Xianhe Lin. Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury[J]. Genes & Diseases, 2023,1(6):2285-2295.
Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury[J]. Genes & Diseases, 2023,1(6):2285-2295. DOI: 10.1016/j.gendis.2022.02.012.
Yu Yang, Xianhe Lin. Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury[J]. Genes & Diseases, 2023,1(6):2285-2295. DOI: 10.1016/j.gendis.2022.02.012.
utophagy is an evolutionarily conserved process involved in the degradation of long-lived proteins and excessive or dysfunctional organelles. As a pivotal cellular response
autophagy has been extensively studied and is known to be involved in various diseases. Ferroptosis is a recently discovered form of regulated cell death characterized by iron overload
leading to the accumulation of lethal levels of lipid hydroperoxides. Recently
an increasing number of studies have revealed a link between autophagy and ferroptosis. Myocardial ischemia/reperfusion injury (MIRI) is an urgent dilemma after myocardial infarction recanalization
which is regulated by several cell death pathways
including autophagy and ferroptosis. However
the potential relationship between autophagy and ferroptosis in MIRI remains unexplored. In this study
we briefly review the mechanisms of autophagy and ferroptosis
including their roles in MIRI. Moreover
we provide an overview of the potential crosstalk in MIRI. Clarifying the relationship between different cell death pathways may provide new ideas for the treatment of MIRI in the future.
AutophagyFerroptosisIron overloadMyocardial ischemia/reperfusion injuryRelationship
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