Objective　To discuss the effect of applying evidence-based medicine（EBM） in orthopedic clinical teaching for eight-year program medical students in military medical university. Methods　Totally 50 eight-year medical students in Shanghai Changzheng Hospital were equally divided into two groups：experimental group（EBM teaching group） and control group. The teacher of experimental group selected appropriate cases and set up the questions according to the difficulties encountered in clinical situation. Students retrieved the relevant medical literature and found out the most useful information for EBM system analysis. The results combined with the current cases were discussed. The teachers summarized clinical experiences and data according to the relevant depart-ment. Traditional direct infusion teaching mode was used in control group. Clinical work experiences were used to guide the students. After-department examination was conducted for both group after finishing the internship and questionnaire investigation was made among students in experiment group. Statistical analysis was carried out on the examination results with SPSS 17.0 software. Mea-surement data were expressed as x±s and comparison on mean differences between two groups was analyzed by t test. Results　Average scores of subjective topic and military related topic in the theory exam were higher in experimental group than in traditional teaching group， with statistically significant differences（P<0.001）. Excellent rate was 80%（20/25） in case discussion in experimental group and 60%（15/25） in control group. Experimental investigation questionnaire showed that： students got enhanced in learning initiative and broadened knowledge. 96%（24/25） students strengthened the learn-ing efficiency of military related chapters. 88%（22/25） students accepted this method and expected to continue. Conclusions　Using the method of evidence-based medicine in eight-year program medical students in military medical university can cultivate the spirit of the stu-dents' self-study actively and rigorous earnest attitude. Students can grasp learning methods and sci-entific thinking. It also can strengthen students' awareness of military medicine and research.