Long-term medical education program requires that the medical students should ac-quire both professional knowledge and scientific research ability. These students， with heavy task and course， have difficulty in performing the scientific research systematically. It is very important to develop the early scientific research training. Department of pathology in Central South University， took early sci-entific research activities in various forms， such as literature searching， reviews writing， research design-ing， experiment performing， lecture communicating and clinical practicing after combining the discipline characteristic and arranging the overall process. Satisfactory effects were achieved with efforts.