Objective　To explore the effect of designing and applying project teaching scheme in higher vocational nursing clinical curriculum. Methods　Sophomores of nursing major in grade 2009 and 2010 were selected as experiment subjects. Lecture-based traditional teaching method was applied in tradition group （121 students in grade 2009） while project teaching was applied in reorga-nization group （128 students in grade 2010）. The teaching method was evaluated through thoretical exam， vocational skill test， professional quality test and questionnaine surrey. Data were input by us-ing SPSS17.00. T-test and Ranksum test were applied. Results　Vocational skill test results of tra-dition group and reorganization group were （76.67±13.072） and （85.48±10.085） respectively； professional quality test results were （74.77±13.865） and （87.04±8.982）， respectively. Differences in both groups had statistical significances（P<0.001）. Evaluation on the teaching method was carried out in both groups through a questionnaire. （716/1408） of students in reorganization group thought that project teaching can improve 11 items including comprehensive quality. Except for the item of the-oretical knowledge comprehension， the rest 10 items of both groups had statistical significances （P<0.001）. Conclusion　Implementation of project teaching in nursing clinical curriculum helps to im-prove students' professional core competence.