In order to adapt to the requirements of modern medical knowledge and skills for higher medical workers， and to cultivate medical students' molecular medicine quality and compre hensive ability， Weifang Medical University broke the boundaries of disciplines and constructed ex perimental course group in molecular medicine based on the ideas of curriculum group construction. Molecular medical knowledge was integrated into the teaching process of experimental course group， experimental teaching content system was reasonably integrated and optimized， high quality teaching team was set up， multi level experimental teaching platform was built and student centered teaching mode was implemented to explore the experimental teaching approach which helped medical students to form systematic molecular medicine knowledge structure and ability structure.