Objective　To explore the effectiveness of blended learning in the clinical teaching of wound care clinic. Methods　Blended learning based on WeChat and offline CBL teaching method was constructed by applying evidence-based nursing. Totally 125 interns from the wound care clinic of our hospital were selected as subjects

among which 62 didn't receive the blended learning (control group)

and 63 received the blended learning (observation group). At the end of the two-week practice

the effectiveness of the two teaching methods was compared. The objective evaluation was carried out in the forms of theory test

practice evaluation and comprehensive quality questionnaire combined with online self-test and offline practice. All data were analyzed by SPSS 20.0 statistical software. Results　The scores of theory test

practice evaluation and comprehensive quality assessment in the observation group were all higher than those in the control group (P<0.001). Conclusion The blended learning with WeChat as the medium can guide student active learning

consolidate the basic knowledge

improve the efficiency of teaching

stimulate the enthusiasm of practice

and improve the comprehensive quality. It's a clinical teaching method that can be used for reference.