The distrbution of Cathopsin D and type I collagen fibera in various typea of adenocarcinoma

villous papillary adenoma and normal mucosa of human coiorectum were investigated by means of immunohistochemical and electronmicroscopical techniques. The results showed that the Cathepsin D distributed in the cytoplasm of type Ⅲmucinous cell carcinoma as well as in the mucous pools of extracellular stroma. The cathepsin D also presented in the cytoplasm of poorly - differentiated adenocarcinoma with rich cytoplasm

whereas the cathepsin D usually was negativc in the tubular adenocarcinoma having more nuclei. Where the mucoua infiltrated

the collagen fibers

smooth muscles and vessels were lysed. The electron microscopc results showed that the secretion function of the type Ⅲmucinous cell carcinoma was high and the collagen fibers adjacent to the type Ⅲ mucinous cell carcinoma was lysed.So the present study suggested that the cathepsin D is able to degrade type mucinous cell carcinoma was lysed.So the present study suggested that the cathepsin D is able to degrade type I and Ⅲ collagen fibers in extracellular stroma and faciliates cancer invasion.