Microvessel quantitation and proliferating activity of tumour cell in breastcarcinoma with correlation to prognosis[J]. Journal of Chongqing Medical University, 1998,(2).
Microvessel quantitation and proliferating activity of tumour cell in breastcarcinoma with correlation to prognosis[J]. Journal of Chongqing Medical University, 1998,(2).DOI:
actor Ⅷ-related antigen and proliferating cell nuclear antigen (PCNA)were examined by immunohistochemistryin 50 cases of imvasive ductal carcinoma of breast.The result showed that microvessel counts(MVCs)in tumour tissue have no correlation with tumour size.(P>0.05)
but levels of PCNA expression inhistological grede Ⅱ、Ⅲ demonstrated significantly higher than those in histological grade I
with significantdifference(P<0.05)
and node-positive carcinoma demonstrated significantly higher levels of PCNA expressionthan those in node-negative carcinoma with significant difference also(P<0.05).Our data indicate that MVChave no useful value as a prognostic predictor.Levels of PCNA expression correlate with histological grade andlymph node statue
PCNA may be a potentially valuable indicator to predict invasive metastasis and prognosis inbreast carcinoma.
关键词
乳腺癌微血管增殖细胞核抗原免疫组织化学
Keywords
breast carcinomamicrovesselImmunohistochemistryProliferating cell nuclear antigen