高强度聚焦超声治疗乳腺癌对腋窝淋巴结形态学的影响

曹友德; 朱辉; 陈文直; 杜永洪; 白晋; 伍烽; 王智彪

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高强度聚焦超声治疗乳腺癌对腋窝淋巴结形态学的影响

更新时间：2024-01-17

- 高强度聚焦超声治疗乳腺癌对腋窝淋巴结形态学的影响
- The morphologic changes of axillary lymph nodes and their significance after HIFU treatment for breast cancer
- 重庆医科大学学报 2001年第2期页码：113-115
- 作者机构：
  
  重庆医科大学医学超声工程研究所,重庆,400016
- 作者简介：
- 基金信息：
  
  国家“九五”科技重点攻关项目（96-905-02-01）;国家自然科学基金项目（39770841）
- DOI：
  中图分类号： R737.9
- 纸质出版日期：2001，
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[1]曹友德,朱辉,陈文直,杜永洪,白晋,伍烽,王智彪.高强度聚焦超声治疗乳腺癌对腋窝淋巴结形态学的影响[J].重庆医科大学学报,2001(02):113-115.

The morphologic changes of axillary lymph nodes and their significance after HIFU treatment for breast cancer[J]. Journal of Chongqing Medical University, 2001,(2):113-115.
[1]曹友德,朱辉,陈文直,杜永洪,白晋,伍烽,王智彪.高强度聚焦超声治疗乳腺癌对腋窝淋巴结形态学的影响[J].重庆医科大学学报,2001(02):113-115. DOI：

The morphologic changes of axillary lymph nodes and their significance after HIFU treatment for breast cancer[J]. Journal of Chongqing Medical University, 2001,(2):113-115. DOI：

摘要

目的：了解高强度聚焦超声（HIFU）治疗乳腺癌后同侧腋窝淋巴结形态变化。方法：23例拟行改良根治术乳腺癌患者，术前1周HIFU治疗。术后对腋窝淋巴结内窦组织细胞（SH）进行分级，并分别用单克隆抗体CD68、S-100对淋巴结内组织细胞、树突状细胞（DC）作免疫组化染色（SP法）并记数。结果：HIFU 治疗后同侧腋窝淋巴结内窦组织细胞（SH）增生明显，以Ⅱ、Ⅲ级为主，而对照组Ⅰ级为主（Ｐ<0.01）；HIFU治疗组中CD68阳性细胞，不仅在淋巴窦内，而且在副皮质区也有较多分布，S-100阳性细胞主要分布于副皮质区。CD68阳性细胞和 S-100 阳性树突状细胞在HIFU治疗组均高于对照组（Ｐ<0.01）。结论：HIFU治疗乳腺癌后同侧腋窝淋巴结细胞免疫功能明显增强。

Abstract

Objective: To research morphologic changes of axillary lymph nodes after HIFU (high intensity focused ultrasound) treatment of breast cancer. Methods: 23 patients with breast cancer had HIFU treatment one week before modified radical mastectomy. After operation

sinus histiocytes in axillary lymph nodes were graded. Monoclonal antibody CD68 and S-100 were used respectively to have immunohistochemistry stain (SP) on histiocytes and dendritic cells

the number of them was taken down. Results: The SH was mainly with Ⅱ and Ⅲ grade in group HIFU

and that in control group wasⅠgrade (Ｐ<0.01). In group HIFU

CD 68 positive cells were distributed with a great amount not only in lymphatic sinus but in paracortical zones

S-100 positive cells were mainly distributed in paracortical zones. In HIFU group

the number of CD68 positive cells and the number of S-100 positive cells were much higher than that of in control group

and obvious difference existed between group HIFU and group control (Ｐ<0.01). Conclusion: HIFU treatment is capable of enhancing the immunological function of axillary lymph nodes.

关键词

乳腺癌腋窝淋巴结窦组织细胞树突状细胞高强度聚焦超声

Keywords

breast cancerAxillary lymph nodeSinus histiocytes(SH)Dendritic cells(DC)High intensity focused ultrasound(HIFU)

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