溃疡病患者胃窦粘膜5-HT细胞和G细胞的变化

王建伟; 周济远; 王亚平; 任君旭; 郑慧娥

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溃疡病患者胃窦粘膜5-HT细胞和G细胞的变化

更新时间：2024-01-17

- 溃疡病患者胃窦粘膜5-HT细胞和G细胞的变化
- Changes of 5-HT and gastrin cells in human antral mucosa during peptic ulcer
- 重庆医科大学学报 2002年第4期页码：394-395
- 作者机构：
  
  1. 张家口医学院组胚教研室,张家口医学院组胚教研室,重庆医科大学基础医学院组胚教研室,张家口医学院组胚教研室,张家口医学院组胚教研室,张家口,075000
  2. ,张家口,075000
  3. 400016,张家口,重庆,075000
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（NO：38970430）
- DOI：
  中图分类号： R573.1
- 纸质出版日期：2002，
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[1]王建伟,周济远,王亚平,任君旭,郑慧娥.溃疡病患者胃窦粘膜5-HT细胞和G细胞的变化[J].重庆医科大学学报,2002(04):394-395+409.

WANG Jianwei, et al. Changes of 5-HT and gastrin cells in human antral mucosa during peptic ulcer[J]. Journal of Chongqing Medical University, 2002,(4):394-395.
[1]王建伟,周济远,王亚平,任君旭,郑慧娥.溃疡病患者胃窦粘膜5-HT细胞和G细胞的变化[J].重庆医科大学学报,2002(04):394-395+409. DOI：

WANG Jianwei, et al. Changes of 5-HT and gastrin cells in human antral mucosa during peptic ulcer[J]. Journal of Chongqing Medical University, 2002,(4):394-395. DOI：

摘要

目的：观察消化性溃疡病患者胃窦粘膜幽门腺5-HT细胞和G细胞的变化。方法：采用免疫组织化学PAP双重染色法，在同一张切片上显示5-HT细胞和G细胞。结果：5-HT细胞多散在于胃窦粘膜的中下1/3，呈棕褐色，形态多样，常见有突起的细胞。G细胞呈带状分布于胃窦粘膜的中1/3，大多数G细胞为蓝色，可见少数细胞为蓝黄混合色，呈圆形或锥体形。5-HT细胞数和G细胞数在胃溃疡（Gu）组分别为：4.25±1.20，7.79±2.11；十二指肠溃疡（Du）组：5.48±1.74，9.34±1.87; 对照（Con）组：3.17±1.65，6.08±1.67。5-HT细胞数和G细胞数在Gu组和Du组都增加，以Du组增加最为明显，与对照组相比均有显著性差异（P<0.01）。结论：胃窦粘膜5-HT细胞和G细胞可能参与了消化性溃疡病的内分泌调节。

Abstract

Objective: To investgate changes of 5-HT and gastrin cells (G cells) in human antral mucosa during peptic ulcer. Methods: The 5-HT cells and G cells were stained with PAP double stainings on the same section. Results: The 5-HT cells were mainly distributed in mid-below third of the mucosa.The cells were brown-yellow.5-HT cells were varied in shape and most of them had long processes. The G cells were located in midzone of the mucosa. Most of them were blue and a few were bluish-yellow. The G cells appeared in different shapes such as spheroid and pyramid. The number of 5-HT cells and G cells were 4.25±1.20

7.79±2.11 in gastric ulcer (Gu)group; 5.48±1.74

9.34±1.87 in duodenal ulcer(Du) group ; 3.17±1.65

6.08±1.67 in control(Con) group respectively. The numbers of 5-HT cells and G cells in gastric ulcer and duodenal ulcer were higher and showed significant difference from those of the control group respectively. Conclusion: It is suggested that 5-HT cells and G cells may participate in the endocrine regulation during peptic ulcer.

关键词

5-HT细胞G细胞PAP双重染色法溃疡病

Keywords

HT cellsG cellsPAP double stainingsPeptic ulcer

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