PENG Hui, et al. Significance of TGF-β2 expression in the retina of diabetic hamster[J]. Journal of Chongqing Medical University, 2006,(6):827-830.DOI:
Objective:To investigate the relations between diabetic retinal damage and the generation of transforming growth factorβ2(TGF-β2)and the function mechanism of TGF-β2.Methods:The diabetic hamster model was established by injection of streptozotocin.The expression of TGF-β2 in the retina of the diabetic hamsters(16w) was determined by immunohistochemicaI technique
Changes of ultrastructure were observed by electron microscope.Results:The reaction for TGF-β2 was negative in normal retina.However
TGF-β2 did express in the retina of diabetic hamsters.Ultrastructure made evident changes.Conclusion:TGF-β2 plays a significant role in the development of diabetic retinopathy.