SHANG Wenjing, et al. The expression of SCF in gastric wall of diabetic gastroparesis rats[J]. Journal of Chongqing Medical University, 2006,(6):824-826.
SHANG Wenjing, et al. The expression of SCF in gastric wall of diabetic gastroparesis rats[J]. Journal of Chongqing Medical University, 2006,(6):824-826.DOI：
Objective: To model diabetic gastroparesis(DGP) in rats and evaluate the role of SCF in the diabetic gastroparesis rats by detecting the level of stem cell factor(SCF) in gastric tissue of diabetic gastroparesis rats in order to discuss the relationship between SCF and DGP.Methods: To model diabetic gastroparesis in rats with intraperitoneal injection of streptozocin(STZ).The models were treated with cisapride for two months
and then the function of gastric emptying of all rats and SCF levels
including mRNA and protein in gastric walls
were detected through reverse transcription polymerase chain reaction(RT-PCR) and western-blotting(WB).Results: The function of gastric emptying was delayed and SCF levels of DGP rats were decreased obviousely.After treated with cisapride
SCF levels
however
were increased
dramatically under the levels of control rats.Conclusion: The stage of DGP seems closely associated with SCF levels in gastric walls of animal models.There may be positive correlation between SCF levels and function of gastric emptying.
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