Objective: To examine the expression of P-gp

GST-π

TOPOП and Ki67 in lung cancer and study the clinical relationship of P-gp

GST-π

TOPOПand Ki67 Co-expression in lung cancer.Methods: The expression of P-gp

GST-π

TOPOП in 52 cases of lung cancer without chemotherapy was detected before operation by immunohistochemical staning.Results: The positive rates of P-gp

GST-π

TOPOП

Ki67 were respectively 73%

80.5%

62.5%

23.7%.The P-gp

GST-π expression was correlated with the histology and differentiation

The expression of TOPOП was obviously lower in adenocarcinoma than in other typers of lung cancers;The coexpression rate of more than one MDR gene production appareatly exceeded individual expression rate.The expression of P-gp

GST-π

TOPOП was not correlated with the expression of Ki67.Conclusion: P-gp

GST-π

TOPOП can be expressed in different types of lung cancers and with different expression levels

They are all correlated with multidrug resistance of lung cancer

Thus

they can be regarded as a valuable indicators for clinical chemotherapy and for prognosis in lung cancer patients.