Objective: To investigate the clinical and pathological factors of intrahepatic recurrence after initial treatment in patients with hepatocelluar carcinoma(HCC).Methods: 57 consecutive patients with pathologically proven recurrent HCC were collected.And these cases were classified into two groups: multicentric occurrence(MO) group and intrahepatic metastasis(IM) based on the type of recurrence.The univariate and multivariate analysis were used for the relationship between the clinical datum and pathological types.Results: Overall recurrence rates after initial treatment were 24.56% at 1 year

47.37% at 2 years

63.16% at 3 years

70.18% at 4 years

and 75.44% at 5 years

respectively.MO was closely associated with hepatitis and AFP concentration

and showed better prognoses.While in patients with IM

the lesions related to the degree of tumor cell differentiation and the majority of recurrences were observed within 3 years.Conclusion: The development and biological behaviors of the MO and IM were quite different.Early detection of intrahepatic recurrence and institute appropriate therapy may prolong survival in patients with MO.