YANG Jiadan, et al. Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats[J]. Journal of Chongqing Medical University, 2007,(6):578-580.
YANG Jiadan, et al. Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats[J]. Journal of Chongqing Medical University, 2007,(6):578-580.DOI:
Objective:To explore the protective effect of sivelestat sodium on cerebral ischemia reperfusion in rats and its mechanism.Methods:The neurons of neonate rat were cultured in vitro.The protective effects of sivelestat sodium on ischemia injury were observed by treating cells in glucose-free and oxygen-free medium.Results:Sivelestat sodium(10-8、10-7 and 10-6mol/L)increased the activity of neurons
reduced the leakage rate of LDH
increased the activity of SOD and reduced the content of MDA.Conclusion:sivelestat sodium protects the neurons against ischemia injury by suppressing the generation of lipid peroxide.