HU Hong, et al. Clinical study of the effect of topotecan in combination with chemotherapy on relapsed and refractory acute myelogenous leukemia[J]. Journal of Chongqing Medical University, 2007,(9):994-995.
HU Hong, et al. Clinical study of the effect of topotecan in combination with chemotherapy on relapsed and refractory acute myelogenous leukemia[J]. Journal of Chongqing Medical University, 2007,(9):994-995.DOI:
Objective:To evaluate the antileukemic activity and side effects of topotecan in patients with refractory and relapsed acute myelogenous leukemia(AML).Method:12cases of refractory and relapsed AML were treated with topotecan combined with chemotherapy
8 accepted 1 course
and the others accepted 2 courses.Result:4 patients achieved complete remission.3 had partial remission.The total response rate was 58%.The main side effect was myelosuppression.Conclusion:The topotecan-based induction therapy has antileukemic effect in some patients with refractory and relapsed AML.