CHEN Yuanyuan, et al. Influence of Polydatin on neuronal apopsis in rat after ischemia reperfusion[J]. Journal of Chongqing Medical University, 2007,(11):1147-1149.
CHEN Yuanyuan, et al. Influence of Polydatin on neuronal apopsis in rat after ischemia reperfusion[J]. Journal of Chongqing Medical University, 2007,(11):1147-1149.DOI:
Objective:To discuss protective mechanism of polydatin(PD)on cerebral ischemia reperfusion injury.Methods:By using rat models of focal cerebral ischemia reperfusion
influence of PD on neuronal apopsis after cerebral ischemia reperfusion injury were examined.Results:Parts of neurons began developing apopsis at 2 hours after reperfusion
.With time passing after reperfusion the number of apoptotic cells increased gradually with peak at 24 hour and thendecreased gradually
The number of apoptotic cells decreased significantly(P<0.05)in PD group at different time points
as compared with model group.Conclusion:On the delayed phase of cerebral ischemia reperfusion injury
apopsis was the main form of neuronal death.PD preserved cerebral ischemia reperfusion by suppressing apopsis.