Objective:To dynamically observe the pathological changes of the optic nerve in EAE.Methods:The animal model was established in Wistar rat.The experiment rats were randomly divided into 8

12

18

and 30day groups.The changes of optic nerve were observed using light and electron microscopes.Results:Under light microscope

the optic nerve fibers showed bulb-like degeneration

the axis irregularity swelling

phlegmonosis cell infiltrating

a quantity of glial cell and collagen tissue formed hyperplastic tissue.Under electron microscopy

the axons showed bulb-like degeneration

myelin sheaths were loose

microtubule and microfilament disappeared.Conclusion:Demyelination occurs in the optic nerve of EAE.By establishing the EAE animail model

we can see the pathological changes of the optic nerve in EAE

which can provide evidences for clinical threatment of this disease.