Objective:To explore the application value of anti-intrarenal artery spasm(IRAS) in renal allografts with unknown ischemia during kidney transplantation. Methods:1. Hot compression:45℃ normal saline gauze was compressed over the grafted kidney and the renal surface was gently rubbed with the fingers;2. Vasodilator:Anisodamine hydrochloride(10～20mg) was injected rapidly into the renal artery. The injection could be repeated one or two times if the blood perfusion of the graft improved;3. Blockage:The adventitia of the renal artery was blocked with 1% lidocaine;4.Dopamine(20～40mg)

papaverine(15～30mg) hydrochloride and 5% glucose in normal saline(500ml) were administered intravenously for three to five days after transplantation. Results:Ischemia disappeared in 8 cases with unknown ischemia reason and the cause was confirmed to be IRAS. Serum creatinine in 8 cases gradually decreased to the normal level on the third to the fifth postoperative days. Conclusion:Anti-IRAS is essential for those with unknown renal ischemia during kidney transplantation

especially for the diagnosis and treatment of IRAS.