Objective:To investigate the efficacy and security of the propofol compounding the SumianxinⅡ for high intensity focusing ultrasound irradiating goats liver in vivo. Methods:thirty Nanjiang yellow goats were randomly divided into two groups

the propofol compounding SumianxinⅡ group(group A

n=15)and the SumianxinⅡgroup(group C

n=15).In group A

the animals were anesthetized with 0.05ml/kg of SumianxinⅡby croup intramuscular injection and 2mg/kg of propofol by intravenous injection

then propofol at rate of 50～150μg/(kg·min) were infused continuously in the whole operation. In group C

the animals were anesthetized with 0.1ml/kg of SumianxinⅡby croup intramuscular injection

and SumianxinⅡwere injected by intravenous injection in the operation. The bucking response in intratracheal intubation

the perioperative hemodynamic changes and recovery profil were observed. Results:Group A restrianed the bucking resonse better than group C(P<0.01). MAP variables were no significant differences at 2min after anesthetized and intubation in group A and C. HR were significant lower at 2min after anesthetized and intubation in group A than group C(P<0.05). HR and MAP were significant lower at 5min and 30min after HIFU treated in group A than group C(P<0.05). Recover time and extubating time were significantly fewer and earlier in group A than group C(P<0.01). Conclusion:The anesthetic effect of propofol compounding SumainxinⅡis more potent than that of SumianxinⅡ

and recovery from anesthesia is faster.