Objective:To study the clinical benefit of propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor. Methods:A total of 126 ASA Ⅰ or Ⅱ aged65 yrs or older patients underwent gastrectomy and rectal surgery were randomly divided into tow groups(n=63 each):group by target-controlled influsion technic modulated(groupⅠ)and group by target-controlled influsion(groupⅡ). CSI of groupⅠwas 50. Propofol of two groups was administered by TCI at a target blood concertration of 2μg/ml during induction of anesthesia and maintenance of anesthesia

sufentanil of two groups was administered by TCI at a target blood concertration of 1.5μg/ml during induction of anesthesia and of 0.3ng/ml during maintenance of anesthesia. MAP

HR

HRV and CSI of the foundation(T1)

intubation(T2)

five minutes after intubation(T3)

chip(T4)

the tumor excision(T5) and the end of surgery(T6) were recorded. And the total of propofol was recorded. Results:MAP at T3

T4 and T5 of groupⅡdecreased obviously compared to that of groupⅠ(P<0.05); HRV of groupⅠat T4 and T5 decreased obviously compared to that of groupⅠ(P<0.05);The undulation with CSI of groupⅠwas less than that of groupⅡ(P<0.05)

the total propofol of groupⅡwas less than that of groupⅠ(P<0.05).Conclusion:Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor was safe and applicable.