Objective:To observe the effects of sea buckthorn procyanidins(SBPC)on MK and platelet activating factor(PAF)in helicobacterpylori-associated gastritis and study the potentional mechanisim.Methods:80 cases were randomized into two groups.42 cases in the SBPC group which were given SBPC and 38 cases in the control group which were given three combined mecidine.TUNEL technique and immunohistochemistry were used to detect the apoptotic cells.Detection on Biospy Specimens of gastric mucosa was done.H.pylori was detected by urease test and Warthin-Starry method and To observe the effects of sea buckthorn procyanidins(SBPC)on the expressions of MK and platelet activating factor(PAF)

which were observed by Immunohischemical and Western blotting method.All of the patients underwent gastroscopy at the 6th week.Results:The difference of apoptotic index between SBPC group and control group had great statistical significance

with the total efficience of SBPC higher than that of control group(P<0.05)

The Immunohischemical and Western blotting method showed that SBPC could reduce the gastic mucosa

s expression of PAF

elevate the expression of MK

but the Control Groups hadn’t this kind of action.Conclusion:The results implied that the possible mechanisims of SBPC are to kill HP

reduce the gastic mucosa

s expression of PAF

and elevate the expression of MK to suppress apoptosis.