Objective:To detect the expression of focal adhesion kinase(FAK) and vascular endothelial growth factor(VEGF)in human laryngeal squamous cell carcinoma to study their correlation in invasion and metastasis.Methods:Immunohistochemical S-P method was used to detect the expression of FAK and VEGF in 42 case of human laryngeal squamous cell carcinoma and 40 cases of polyp of vocal cords.All the samples were stained by HE method to confirm their pathologic characteristics.Positive rates of FAK and VEGF were evaluated by microscopy.Results:The positive rates of FAK

VEGF were 79% and 71%

respectively in human laryngeal squamous cell carcinoma.While in polyp of vocal cords

13% and 18%

respectively.The difference was significant(P<0.05).Moreover

the expression of FAK and VEGF were higher in the specimens with invasion than that these without invasion and lymph node metastasis(P<0.05).There was a positive relationship between FAK and VEGF in the same sample(r=0.581

P<0.05).Conclusion:FAK and VEGF play a key role in the invasion and metastasis of laryngeal squamous cell carcinoma and might prognosticate invasion and metastasis.