Objective:To explore the relationship between genetic polymorphism of ALDH2 and CYP2E1 and alcoholic liver disease(ALD) in Han people. Methods:PCR-RFLP was used to detect the frequencies of gene types and allele of ALDH and CYP2E1 in health control group(45 cases)

ALD group(48 cases)

alcohol dependent group(38 cases) and non-ALD(NALD) group(42 cases)

and the frequencies were compared. Results:The difference of the frequencies of ALDH2*1 and ALDH2*2 had statistic significance between health control group and ALD group

and between in ALD group and NALD group(P<0.05). ALDH2*1 was the main gene type for alcohol dependent group and ALD group. The frequency of CYP2E1 c1 and c2 had statistically significant difference from the orther three groups(P<0.05). Conclusion:The gene polymorphism of ALDH2 has close relationship to the pathogenesis of ALD. ALDH*2 allele may be a negative risk factor for alcoholism and ALD in Chinese Han people. The gene polymorphism of CYP2E1 has close relationship to the pathogenesis of ALD. The genotype of B(c1/c2)plays a important role in the development of ALD and c2 allele is relevant to the pathogenesis of ALD.