Objective:To observe neuroprotective effects of insulin on traumatic spinal cord injury in rat models and discuss its potential mechanisms. Methods:60 SD rats were randomly divided into A group(control group) and B group(insulin group)

with 30 rats in each group

The animal SCI model was established according to method Allen’s

A group and B group were respectively infused with isotonic Na chloride or 1Iu/kg insulin through abdominal cavity

three times a day

for 7 days. apoptosis neurons were observed on 8 hours

3 days

7 days

14 days

and 28 days after SCI

and tigroid body

neurons

GAP-43 positive cells

and BBB score were measured on 1 day

3 days

7 days

14 days

and 28 days after SCI. Results:Neuron number

GAP-43 positive cells

and BBB score in multitude time points were significantly higher in B group than in A group(P<0.05 or P<0.01). The number of apoptosis neurons in B group was less than in A group’s(P<0.05 or P<0.01). Conclusions:Insulin has neuroprotective effects on traumatic spinal cord injury in rat models. It can promote recovery of function by depressing apoptosis of neurons and promoting recovery and regeneration of neuraxon.