YING Chuan-min, et al. The expression and significance of signaling adaptor protein Crk in cervix cancer[J]. Journal of Chongqing Medical University, 2008,(7):792-795.
YING Chuan-min, et al. The expression and significance of signaling adaptor protein Crk in cervix cancer[J]. Journal of Chongqing Medical University, 2008,(7):792-795.DOI：
Objective:To investigate the expression of signaling adaptor protein Crk in cervix cancer
cervical intraepithelial neoplasias(CINs) and normal cervix
and evaluate their relationship with the invasive and metastatic capacity of cervical carcinoma. Methods:Expression of Crk protein was detected by immunostaining in 20 cases of normal cervix
27 cases of CINs and 50 cases of cervix cancer. Result:Immunostaining revealed that Crk protein was expressed in 68% of cervix cancer
40.7% of CINs and 10% of normal cervix. Conclusion:Over-expression of Crk may play an important role in the development of CINs and cervix cancer. Crk could be used a malignant biomarker of cervix cancer.
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