Objective:To find the effect of the abnormity of hypothalamus-pituitary-hypothyroid axis on cerebral infarction onset. Methods: Objects were divided into 3 groups: cerebral infarction group(CIG)、persons with cerebral infarction risk factor group(CIRG) and control group(CG) .The concentration of serum T3、T4、TSH、TGA and TMA on an empty stomach in each group were measured respectively by radioimmunoassay

and results were compared between each two groups by using Student t test. Results:Compared with CIRG and CG

the levels of T3、T4 in the sample of CIG were lower

and the level of TSH were higher

and there was distinctly difference(P<0.01);The level of T3 in CIRG was higher than that of CG

and there was distinctly difference(P<0.01);Compared with CG

the level of T4 was higher and the level of TSH was lower in CIRG

but there was no distinctly difference between CIRG and CG(P>0.01). Conclusion:This study indicated that the function of hypothalamus-pituitary-hypothyroid axis was abnormity in patients with cerebral infarction and those persons with cerebral infarctive risk factor.