预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的对比研究

南映瑜; 龙波; 钟艺华; 张蕴蕴; 黄恬; 唐显军

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预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的对比研究

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- 预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的对比研究
- A comparison of premixed insulin aspart 30 and premixed human insulin 30R in treatment of type 2 diabetes
- 重庆医科大学学报 2009年34卷第3期页码：379-381
- 作者机构：
  
  重庆市肿瘤研究所内科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R587.1
- 纸质出版日期：2009，
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[1]南映瑜,龙波,钟艺华,张蕴蕴,黄恬,唐显军.预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的对比研究[J].重庆医科大学学报,2009,34(03):379-381.

NAN Ying-yu. A comparison of premixed insulin aspart 30 and premixed human insulin 30R in treatment of type 2 diabetes[J]. Journal of Chongqing Medical University, 2009,34(3):379-381.
[1]南映瑜,龙波,钟艺华,张蕴蕴,黄恬,唐显军.预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的对比研究[J].重庆医科大学学报,2009,34(03):379-381. DOI：

NAN Ying-yu. A comparison of premixed insulin aspart 30 and premixed human insulin 30R in treatment of type 2 diabetes[J]. Journal of Chongqing Medical University, 2009,34(3):379-381. DOI：

摘要

目的:探讨每日2次注射预混门冬胰岛素30（诺和锐30）和预混人胰岛素30R（诺和灵30R）治疗2型糖尿病患者的疗效和安全性。方法:68例经口服降糖药物控制不佳的2型糖尿病患者被随机分为诺和锐30治疗组和诺和灵30R治疗组

分别采用每日早

晚餐前注射诺和锐30和诺和灵30R

进行为期12周的观察。比较两组患者糖化血红蛋白（HbA1c）

7个时点血糖

低血糖发生频率等。结果:诺和锐30治疗组的早

晚餐后血糖明显低于诺和灵30R治疗组（P<0.01）;诺和锐30治疗组低血糖发生次数低于诺和灵30R治疗组

但差异无统计学意义（P>0.05）

诺和锐30治疗组无严重低血糖发生。结论:对于2型糖尿病患者

每天2次注射诺和锐30较诺和灵30R能更明显地降低餐后血糖及减少低血糖风险

同时更易于为患者接受。

Abstract

Objective:To compare the safety and efficacy of premixed insulin aspart 30 (BIAsp30) with premixed human insulin 30R (BHI30)used in twice-daily injection regimen in patients with type 2 diabetes. Methods:Sixty-eight patients with inadequate glycemia control by oral drug were randomly divided into two groups using twice-daily insulin for 12 weeks comparison of BIAsp30 and BHI30. We compared HbA1c

seven-point blood glucose and frequency of hypoglycemia in two groups. Results:Blood glucose after breakfast and after dinner were significantly lower in BIAsp30 group than in BHI30 group(P<0.01). The number of hypoglycemic episodes was less in BIAsp30 group than in BHI30 group

but the contrast had no statistical significance(P>0.05)

meanwhile no serious hypoglycemia happened in BIAsp30 group. Conclusion:Post-prandial glycemia control was significantly improved

without increasing the risk of hypoglycemia

when people with type 2 diabetes were treated in twice-daily injection regimen with BIAsp30

as compared with BHI30.

关键词

门冬胰岛素预混胰岛素2型糖尿病

Keywords

InsulinaspartPremixedinsulintype2diabetes

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