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重庆医科大学附属第一医院急诊科
纸质出版日期:2009,
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[1]杨远征,刘琼,徐昉.急性重症毒蕈中毒心肌损害临床研究[J].重庆医科大学学报,2009,34(03):382-384.
YANG Yuan-zheng, et al. Clinical study of severe acute mushroom poisoning with myocardial damage[J]. Journal of Chongqing Medical University, 2009,34(3):382-384.
目的:探讨急性重症毒蕈中毒心肌损害及对预后的影响。方法:收集我院1998~2007年18例急性重症毒蕈中毒患者临床资料
对其进行回顾性分析
比较治疗前后的生化指标变化。结果:18例急性重症毒蕈中毒不仅有胃肠道、肝、肾毒性作用
心肌的毒性作用尤为突出
主要表现为心肌酶谱增高、心电图改变及恶性心律失常。给予常规解毒、心肌保护、抗心律失常、血液净化等综合治疗后
血CR、BUN、ALT、AST、LDH、CK、C-MB、HBDH明显下降
治疗前后有显著性差异(P<0.05)
全组死亡2例
均死于室性心动过速。结论:重症毒蕈中毒具有明显心肌毒性作用
易引起恶性心律失常
是死亡的主要原因。运用血液灌流和血液透析等综合治疗
疗效显著
改善预后。
Objective:To explore severe acute mushroom poisoning with myocardial damage and the prognosis of the patient. Method: The clinical data of 18 cases of severe acute mushroom poisning treated from 1998 to 2007 in my hospital were collected and analyed retrospectively
and the biochemical indicators were compared. Results:18 cases of severe acute mushroom poisoning not only presented the gastrointestinal tract
liver
kidney toxicity
but particularly prominent cardiac toxicity
mainly as increase of myocardial enzymes
electrocardiogram changes and malignant arrhythmia. Given conventional detoxication
myocardial protection
anti-arrhythmia
blood purification treatment and so on
the patients showed a significant decline in serum concentrations of CR
BUN
ALT
AST
LDH
CK
CK-MB
and HBDH. The differences between pre-treatment and post-treatment indicators in both groups were significant (P<0.05). 2 patients died of ventricular tachycardia in the whole group. Conclusion:Severe mushroom poisoning have significant cardiac toxicity and easily cause malignant arrhythmia
is the leading cause of death. Blood perfusion
blood dialysis and other combined treatment
are significantly effective and improve the prognosis of the patients.
毒蕈中毒心肌损害鹅膏毒肽鬼笔毒肽
Mushroompoisningmyocardialdamagyamanitinsphallotoxins
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