Objective:Observe the effects of fastigial nucleus stimulation(FNS) on spatial memory and learning ability of the Aβ1-40 induced Alzheimer rat model

by detecting GFAP expression of hippocampus area. Methods:Aβ1-40 was microinjected into the right hippocampus of rats. Cerebella dentate nucleus and fastigial nucleus were stimulated separately before the model was made in interference group. The spatial memory and learning ability of the rat was evaluated by the Morris water maze procedure at the 28th days after injection. The expression of GFAP in astrocyte cell was determined with immunohistochemistry method.Results:The AD rats received FNS showed significant shorter escape latency than the group without FNS(P<0.05).Aβ1-40 could increase the optical density of positive cells of GFAP(P<0.05)

FNS could reduce the optical density of positive cells of GFAP(P<0.05)

but in dentate nucleus stimulation group no such effect was found. Conclusion:FNS can partly improve the spatial learning and memory dysfunction of AD rat by inhibits the expression of GFAP of hippocampus area and decrease the activity of astrocyte cell.