Objective:To study the effects of the fastigial nucleus electrostimulation on the ability of learning and memory and the Apoptosis of the neurons in the hippocampal district in ratymodel of Alzheimer’s D isease induced byβ-amyloid(Aβ).Methods:Forty rats were randomly divided into:Aβ1-40 micro-injection groups(AD)

sham-operation roup(SC)

Aβ1-40 micro-injection and fastigial nucleus stimulation group(FNS)

a Aβ1-40 micro-injection and corpus dentatum stimulation group(DNS).The effect of fastigial nucleus electrostimulation on learning and memory retention disorder in the model rats was studied by the test of Morris water maze;the brain protection of fastigial nucleus electrostimulation in model rats was observed through pathomorphology changes;the Apoptosis of the neurons in the hippocampal CA1 district was detected by Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling method.Results:The escape latency of the place navigation in the AD grou

FNS group and DNS group were singnificiantly longer than that in the SC group(P<0.05).The number of apoptotic neurons in the hippocampal CA1 district of the AD group was significantly different from that in the sham injection group(P<0.05).The AD rats received FNS showed significiant shorter escape latency than AD rat(sP<0.05).The number of apoptotic neurons in the hippocampal CA1 district of the FNS group(22.55±2.74)was significantly different from that of the AD group(36.90±4.07)(P<0.05).Conclusions:FNS can improve the spatial learning and memory dysfunction of AD rat

implying that FNS has the function to restraining the apoptosis of the hippocampal neurons.