Objective:To study the effects of FuYuan capsule on rat liver fibrosis induced by pig serum.Methods:The rats were randomly divided into six groups

including the normal group

the model group

the low

middle and high dose FuYuan capsule group

and the positive control group(compound Biejiaruangan-chip solution).The rat models of immune liver fibrosis were induced with pig serum.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in serum were detected with autoumatic biochemical analyzer.Hyaluronan(HA)

laminin(LN).IV collagen(IV-C)and the typeⅢcollagen(PCⅢ)in serum were quantified by radiative-immune technology.The expression of TIMP-1(tissue inhibitor of metalloproteinases-1)and TGF-β1(transforming growth factorβ-1)in the liver were observed by immunohistochemical assay.Results:ALT

AST

HA

LN

IV-C and PCⅢin the model group were significantly higher than those in the other group(sP<0.05)

and there were significant difference between the model group and the FuYuancapsulegroup(sP<0.05)

especiallythehigh-dosegroup.Compared with that in model group

the expression of TIMP-1andTGF-β1 in the Fuyuan groups were significantly lowe(rP<0.05)

especially in the high-dose group.Conclusion:The protective effects of FuYuan capsule on the pig serum-induced liver fibrosis are remarkable.